25T2-NBOMe

In today's world, 25T2-NBOMe has become a topic of great relevance and interest to people in different areas of society. From the academic field to the workplace, 25T2-NBOMe has generated debates, reflections and analyzes that have influenced the way we make decisions, relate to others and perceive the world around us. In this article, we will explore different perspectives and opinions about 25T2-NBOMe, with the aim of offering a comprehensive and balanced view on this complex and fascinating topic.

25T2-NBOMe
Clinical data
Other names2C-T-2-NBOMe; NBOMe-2C-T-2; N-(2-Methoxybenzyl)-4-ethylthio-2,5-dimethoxyphenethylamine
Drug classSerotonin 5-HT2 receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Identifiers
  • 2-(4-ethylsulfanyl-2,5-dimethoxyphenyl)-N-ethanamine
CAS Number
PubChem CID
Chemical and physical data
FormulaC20H27NO3S
Molar mass361.50 g·mol−1
3D model (JSmol)
  • CCSC1=C(C=C(C(=C1)OC)CCNCC2=CC=CC=C2OC)OC
  • InChI=1S/C20H27NO3S/c1-5-25-20-13-18(23-3)15(12-19(20)24-4)10-11-21-14-16-8-6-7-9-17(16)22-2/h6-9,12-13,21H,5,10-11,14H2,1-4H3
  • Key:OZEBFZPAWCXEGK-UHFFFAOYSA-N

25T2-NBOMe is a serotonergic psychedelic of the 25-NB (NBOMe) family.[1][2][3][4][5][6] It is the NBOMe analogue of 2C-T-2.[1][2][3][4][5][6] The drug acts as a highly potent and selective agonist of the serotonin 5-HT2 receptors.[7] Its reported active dose range has been described as 100 to 1,000 μg, with a typical dose estimate of 500 μg.[8] 25T2-NBOMe was first described in the scientific literature by at least 2012.[9]

See also

References

  1. ^ a b Herian M, Świt P (January 2023). "25X-NBOMe compounds - chemistry, pharmacology and toxicology. A comprehensive review". Crit Rev Toxicol. 53 (1): 15–33. doi:10.1080/10408444.2023.2194907. PMID 37115704.
  2. ^ a b Gil-Martins E, Barbosa DJ, Borges F, Remião F, Silva R (June 2025). "Toxicodynamic insights of 2C and NBOMe drugs - Is there abuse potential?". Toxicol Rep. 14: 101890. Bibcode:2025ToxR...1401890G. doi:10.1016/j.toxrep.2025.101890. PMC 11762925. PMID 39867514.
  3. ^ a b Zawilska JB, Kacela M, Adamowicz P (2020). "NBOMes-Highly Potent and Toxic Alternatives of LSD". Front Neurosci. 14: 78. doi:10.3389/fnins.2020.00078. PMC 7054380. PMID 32174803.
  4. ^ a b Kyriakou C, Marinelli E, Frati P, Santurro A, Afxentiou M, Zaami S, Busardo FP (September 2015). "NBOMe: new potent hallucinogens--pharmacology, analytical methods, toxicities, fatalities: a review" (PDF). Eur Rev Med Pharmacol Sci. 19 (17): 3270–3281. PMID 26400534.
  5. ^ a b Halberstadt AL (2017). "Pharmacology and Toxicology of N-Benzylphenethylamine ("NBOMe") Hallucinogens". Neuropharmacology of New Psychoactive Substances (NPS). Curr Top Behav Neurosci. Vol. 32. pp. 283–311. doi:10.1007/7854_2016_64. ISBN 978-3-319-52442-9. PMID 28097528.
  6. ^ a b Marchi NC, Scherer JN, Fara LS, Remy L, Ornel R, Reis M, Zamboni A, Paim M, Fiorentin TR, Wayhs CA, Von Diemen L, Pechansky F, Kessler FH, Limberger RP (2019). "Clinical and Toxicological Profile of NBOMes: A Systematic Review". Psychosomatics. 60 (2): 129–138. doi:10.1016/j.psym.2018.11.002. PMID 30606495.
  7. ^ Rickli A, Luethi D, Reinisch J, Buchy D, Hoener MC, Liechti ME (December 2015). "Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs)" (PDF). Neuropharmacology. 99: 546–553. doi:10.1016/j.neuropharm.2015.08.034. PMID 26318099.
  8. ^ Luethi D, Liechti ME (October 2018). "Monoamine Transporter and Receptor Interaction Profiles in Vitro Predict Reported Human Doses of Novel Psychoactive Stimulants and Psychedelics". Int J Neuropsychopharmacol. 21 (10): 926–931. doi:10.1093/ijnp/pyy047. PMC 6165951. PMID 29850881.
  9. ^ Casale, J. F., & Hays, P. A. (2012). Characterization of eleven 2, 5-dimethoxy-N-(2-methoxybenzyl) phenethylamine (NBOMe) derivatives and differentiation from their 3-and 4-methoxybenzyl analogues—part I. Microgram Journal, 9(2), 84–109. https://www.dea.gov/sites/default/files/pr/microgram-journals/2012/mj9_84-109.pdf



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