AVN-211

In this article we will explore various facets related to AVN-211, a topic that has captured the attention and interest of people around the world. Since its emergence, AVN-211 has sparked curiosity and debate, and its impact has been felt in different areas of society. Throughout this writing, we will immerse ourselves in the analysis and reflection on AVN-211, addressing its implications, its evolution over time and its relevance today. Through this article, we seek to provide a comprehensive and enriching view on AVN-211, with the goal of giving the reader a deeper and more nuanced understanding of this highly relevant topic.

AVN-211
Clinical data
Other namesCD-008-0173
Identifiers
  • 5,7-dimethyl-2-(methylsulfanyl)-3-(phenylsulfonyl)pyrazolopyrimidine
CAS Number
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H15N3O2S2
Molar mass333.42 g·mol−1
3D model (JSmol)
  • Cc1cc(n2c(n1)c(c(n2)SC)S(=O)(=O)c3ccccc3)C
  • InChI=1S/C15H15N3O2S2/c1-10-9-11(2)18-14(16-10)13(15(17-18)21-3)22(19,20)12-7-5-4-6-8-12/h4-9H,1-3H3
  • Key:KSAUCBGUWGWPDL-UHFFFAOYSA-N

AVN-211 (CD-008-0173) is a drug which acts as a highly selective 5-HT6 receptor antagonist and is under development by Avineuro Pharmaceuticals for the treatment of schizophrenia.[1][2][3] In early 2011, it successfully completed phase IIa clinical trials,[1][4] with benefits on positive symptoms and some procognitive effects observed,[5] and in mid 2013, phase IIb clinical trials for schizophrenia began.[6] Avineuro Pharmaceuticals also expressed intention to start clinical trials of AVN-211 for Alzheimer's disease in 2015.[6][7][needs update]

See also

References

  1. ^ a b Ellenbroek BA, Cesura AM (13 October 2014). "Antipsychotics and the Dopamine-Serotonin Connection". In Celanire S, Poli S (eds.). Small Molecule Therapeutics for Schizophrenia. Springer. pp. 31, 37. ISBN 978-3-319-11502-3.
  2. ^ Pharmacology of 5-HT6 receptors. Academic Press. 7 December 2010. pp. 164–. ISBN 978-0-12-384977-9.
  3. ^ "Drug Development in Schizophrenia: Summary and Table". Pharmaceutical Medicine. 28 (5): 265–271. 2014. doi:10.1007/s40290-014-0070-6. ISSN 1178-2595. S2CID 8513976.
  4. ^ "Avineuro Pharmaceuticals, Inc. Reports positive Phase 2a clinical proof of concept trial results on AVN-211, potent small molecule for treatment of schizophrenia". Avineuro Pharmaceuticals, Inc.
  5. ^ Morozova MA, Lepilkina TA, Rupchev GE, Beniashvily AG, Burminskiy DS, Potanin SS, et al. (August 2014). "Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study". CNS Spectrums. 19 (4): 316–323. doi:10.1017/S1092852913000394. PMID 23768250. S2CID 25486838.
  6. ^ a b "Avineuro Pharmaceuticals, Inc. Announces beginning of Phase 2b clinical studies of AVN-211, potent small molecule for treatment of schizophrenia". Avineuro Pharmaceuticals, Inc.
  7. ^ Ivachtchenko AV, Lavrovsky Y, Ivanenkov YA (March 2016). "AVN-211, Novel and Highly Selective 5-HT6 Receptor Small Molecule Antagonist, for the Treatment of Alzheimer's Disease". Molecular Pharmaceutics. 13 (3): 945–963. doi:10.1021/acs.molpharmaceut.5b00830. PMID 26886442.
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