4-HO-MPMI

In the modern world, 4-HO-MPMI has become a topic of great relevance and interest to numerous sectors of society. Its influence ranges from the personal to the professional sphere, including the impact it has on culture and technology. There are many debates and reflections that revolve around 4-HO-MPMI, and its importance is undeniable today. That is why it is essential to delve into its different facets and understand its scope and implications in our daily lives. In this article, we will explore some of the most relevant perspectives on 4-HO-MPMI and how it affects society at large.

4-HO-MPMI
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class A
Identifiers
  • (R)-3-(N-methylpyrrolidin-2-ylmethyl)-4-hydoxyindole
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H17N2O
Molar mass229.303 g·mol−1
3D model (JSmol)
  • OC1=C2C(C3()CCCN3C)=CNC2=CC=C1
  • InChI=1S/C14H18N2O/c1-16-7-3-4-11(16)8-10-9-15-12-5-2-6-13(17)14(10)12/h2,5-6,9,11,15,17H,3-4,7-8H2,1H3/t11-/m1/s1 ☒N
  • Key:XYRKPZYRLSWABB-LLVKDONJSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

4-HO-MPMI (also known as 4-Hydroxy-N-methyl-(α,N-trimethylene)-tryptamine or lucigenol) is a tryptamine derivative that is a psychedelic drug. It was developed by the team led by David Nichols from Purdue University in the late 1990s. This compound produces hallucinogen-appropriate responding in animal tests with a similar potency to the amphetamine-derived psychedelic DOI, and has two enantiomers, with only the (R)-enantiomer being active.[1]

The binding affinity for 5-HT2A receptor is 13 ± 2 nM (Ki DOI). It is reported at doses starting at 0.5 mg and 1.0-1.5 mg seem to be psychedelic doses. The duration it is reported between six and eight hours. Available (anecdotal) data on subjective effects report open- and closed-eye visuals, sedation, and anxiety.[2]

See also

References

  1. ^ Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE (1999). "Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain". Journal of Medicinal Chemistry. 42 (20): 4257–4263. CiteSeerX 10.1.1.690.4941. doi:10.1021/jm990325u. PMID 10514296.
  2. ^ "Lucigenol Info - Hip Forums". Archived from the original on 2011-07-11. Retrieved 2010-08-02.