JWH-116

In this article, we will explore the topic of JWH-116 in depth, analyzing its most relevant aspects and its impact in different contexts. From its origins to its current evolution, we will delve into the details that have characterized JWH-116 over time, as well as the future perspectives that are envisioned around this topic. Through a multidisciplinary approach, we will examine how JWH-116 has influenced different areas, from culture to science, politics and society in general. Likewise, we will reflect on the implications that JWH-116 has had on people's daily lives, as well as on the global panorama. Ultimately, this article seeks to provide a comprehensive view of JWH-116, providing the reader with a deep and enriching understanding of this exciting topic.

JWH-116
Legal status
Legal status
Identifiers
  • (2-Ethyl-1-pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
CAS Number
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H27NO
Molar mass369.508 g·mol−1
3D model (JSmol)
  • CCCCCN1C2=CC=CC=C2C(=C1CC)C(=O)C3=CC=CC4=CC=CC=C43
  • InChI=1S/C26H27NO/c1-3-5-10-18-27-23(4-2)25(22-15-8-9-17-24(22)27)26(28)21-16-11-13-19-12-6-7-14-20(19)21/h6-9,11-17H,3-5,10,18H2,1-2H3
  • Key:AQHPTHKEKSWGPO-UHFFFAOYSA-N

JWH-116 is a synthetic cannabinoid receptor ligand from the naphthoylindole family. It is the indole 2-ethyl derivative of related compound JWH-018. The binding affinity of JWH-116 for the CB1 receptor is reported as Ki = 52 ± 5 nM.[1]

In the United States, all CB1 receptor agonists of the 3-(1-naphthoyl)indole class such as JWH-116 are Schedule I Controlled Substances.[2]

See also

References

  1. ^ Huffman JW, Mabon R, Wu MJ, Lu J, Hart R, Hurst DP, et al. (February 2003). "3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor". Bioorganic & Medicinal Chemistry. 11 (4): 539–49. doi:10.1016/s0968-0896(02)00451-0. PMID 12538019. S2CID 29107765.
  2. ^ 21 U.S.C. § 812: Schedules of controlled substances
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