O-1918

In this article, we will explore the fascinating world of O-1918, a topic that has captured the attention of many people over time. From its impact on society to its implications in everyday life, O-1918 has been the subject of debate and analysis by experts in various disciplines. Whether we're talking about its influence on history, its relevance in today's world, or its projections into the future, O-1918 remains a topic of interest and curiosity for many. Throughout this article, we will examine different aspects of O-1918, from its origins to its possible repercussions, with the aim of providing a broad and detailed overview of this exciting topic.

O-1918
Identifiers
  • 1,3-dimethoxy-5-methyl-2-benzene
CAS Number
PubChem CID
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H26O2
Molar mass286.415 g·mol−1
3D model (JSmol)
  • CC1=C(C2=C(OC)C=C(C)C=C2OC)(C(C)=C)CC1

O-1918 is a synthetic compound related to cannabidiol, which is an antagonist at two former orphan receptors GPR18 and GPR55, that appear to be related to the cannabinoid receptors. O-1918 is used in the study of these receptors, which have been found to be targets for a number of endogenous and synthetic cannabinoid compounds, and are thought to be responsible for most of the non-CB1, non-CB2 mediated effects that have become evident in the course of cannabinoid research.[1][2][3][4][5]

Subsequent research by using electrophysiological approach has shown that O-1918 is a potent BKCa channel inhibitor.[6][7][8]

See also

References

  1. ^ Offertáler L, Mo FM, Bátkai S, Liu J, Begg M, Razdan RK, et al. (March 2003). "Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor". Molecular Pharmacology. 63 (3): 699–705. doi:10.1124/mol.63.3.699. PMID 12606780.
  2. ^ Zakrzeska A, Schlicker E, Baranowska M, Kozłowska H, Kwolek G, Malinowska B (June 2010). "A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats". British Journal of Pharmacology. 160 (3): 574–84. doi:10.1111/j.1476-5381.2009.00579.x. PMC 2931558. PMID 20105178.
  3. ^ Schuelert N, McDougall JJ (August 2011). "The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55". Neuroscience Letters. 500 (1): 72–6. doi:10.1016/j.neulet.2011.06.004. PMID 21683763. S2CID 3410391.
  4. ^ Szczesniak AM, Maor Y, Robertson H, Hung O, Kelly ME (October 2011). "Nonpsychotropic cannabinoids, abnormal cannabidiol and canabigerol-dimethyl heptyl, act at novel cannabinoid receptors to reduce intraocular pressure". Journal of Ocular Pharmacology and Therapeutics. 27 (5): 427–35. doi:10.1089/jop.2011.0041. PMID 21770780.
  5. ^ Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A (June 2013). "A GPR18-based signalling system regulates IOP in murine eye". British Journal of Pharmacology. 169 (4): 834–43. doi:10.1111/bph.12136. PMC 3687663. PMID 23461720.
  6. ^ Godlewski G, Offertáler L, Osei-Hyiaman D, Mo FM, Harvey-White J, Liu J, et al. (January 2009). "The endogenous brain constituent N-arachidonoyl L-serine is an activator of large conductance Ca2+-activated K+ channels". The Journal of Pharmacology and Experimental Therapeutics. 328 (1): 351–361. doi:10.1124/jpet.108.144717. PMC 2605781. PMID 18923087.
  7. ^ Bondarenko AI, Panasiuk O, Drachuk K, Montecucco F, Brandt KJ, Mach F (March 2018). "The quest for endothelial atypical cannabinoid receptor: BKCa channels act as cellular sensors for cannabinoids in in vitro and in situ endothelial cells". Vascular Pharmacology. 102: 44–55. doi:10.1016/j.vph.2018.01.004. PMC 6481560. PMID 29355732.
  8. ^ Bondarenko AI, Panasiuk O, Okhai I, Montecucco F, Brandt KJ, Mach F (June 2017). "Direct activation of Ca2+ and voltage-gated potassium channels of large conductance by anandamide in endothelial cells does not support the presence of endothelial atypical cannabinoid receptor". European Journal of Pharmacology. 805: 14–24. doi:10.1016/j.ejphar.2017.03.038. PMC 6520242. PMID 28327344.