Nonabine

In this article we will talk about Nonabine and its relevance in different contexts. Nonabine has become a topic of interest and debate in today's society, since its impact ranges from personal aspects to global repercussions. Throughout history, Nonabine has played a fundamental role in various spheres, influencing the way we relate, consume information, and make decisions. In this article we will explore the different aspects that make Nonabine an important topic today, as well as its evolution over time and its influence on contemporary society.

Nonabine
Clinical data
ATC code
  • none
Legal status
Legal status
  • Not approved for any medical use
Identifiers
  • 7-(1,2-Dimethylheptyl)-2,2-dimethyl-4-(4-pyridinyl)-2H-1-benzopyran-5-ol
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC25H33NO2
Molar mass379.544 g·mol−1
3D model (JSmol)
  • CCCCCC(C)C(C)c1cc(c2c(c1)OC(C=C2c3ccncc3)(C)C)O
  • InChI=1S/C25H33NO2/c1-6-7-8-9-17(2)18(3)20-14-22(27)24-21(19-10-12-26-13-11-19)16-25(4,5)28-23(24)15-20/h10-18,27H,6-9H2,1-5H3 ☒N
  • Key:YHUDSHIRWOVVCV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Nonabine (BRL-4664) is an experimental drug which is a synthetic THC analog.[1] It was studied in the 1980s for the prevention of nausea and vomiting associated with cancer chemotherapy but was never marketed.[1] It has strong antiemetic effects equivalent to those of chlorpromazine, and also produces some mild sedative effects, along with dry mouth and EEG changes typical of cannabinoid agonists, but with minimal changes in mood or perception, suggesting the abuse potential is likely to be low.[2][3]

References

  1. ^ a b Staquet M, Bron D, Rozencweig M, Kenis Y (1981). "Clinical studies with a THC analog (BRL-4664) in the prevention of cisplatin-induced vomiting". Journal of Clinical Pharmacology. 21 (S1): 60S – 63S. doi:10.1002/j.1552-4604.1981.tb02575.x. PMID 7197692. S2CID 30609591.
  2. ^ Archer CB, Amlot PL, Trounce JR (January 1983). "Antiemetic effect of nonabine in cancer chemotherapy: a double blind study comparing nonabine and chlorpromazine". British Medical Journal. 286 (6362): 350–1. doi:10.1136/bmj.286.6362.350-a. PMC 1546960. PMID 6402096.
  3. ^ McClelland GR, Sutton JA (1985). "Pilot investigation of the quantitative EEG and clinical effects of ketazolam and the novel antiemetic nonabine in normal subjects". Psychopharmacology. 85 (3): 306–8. doi:10.1007/BF00428192. PMID 2860687. S2CID 19560039.
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