AM-11245

In this article, we will explore the powerful story of AM-11245, a topic that has captured the imagination of people of all ages and from different parts of the world. From its origins to its relevance today, we will delve into the profound influence that AM-11245 has had on society and culture. Through a comprehensive and detailed analysis, we will discover the most fascinating and surprising aspects of AM-11245, as well as its meaning and relevance in the contemporary world. Prepare to be surprised and moved by the extraordinary story of AM-11245.

AM-11245
Identifiers
  • 8-chromen-3-yl]-8-methylnonanenitrile
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC26H39NO3
Molar mass413.602 g·mol−1
3D model (JSmol)
  • CC1(C)OC2=C(31CC(CO)C3)C(O)=CC(C(C)(C)CCCCCCC#N)=C2
  • InChI=1S/C26H39NO3/c1-25(2,12-8-6-5-7-9-13-27)19-15-22(29)24-20-14-18(17-28)10-11-21(20)26(3,4)30-23(24)16-19/h15-16,18,20-21,28-29H,5-12,14,17H2,1-4H3/t18-,20-,21-/m1/s1
  • Key:IGSAQGJQMKOTAG-HMXCVIKNSA-N

AM-11245 is a drug which is a cannabinoid agonist from the classical cannabinoid family. It has high affinity and efficacy at both the CB1 and CB2 cannabinoid receptors, with a Ki of 0.4nM at both CB1 and CB2, and an EC50 of ~0.06nM at CB1 and 0.2nM at CB2, making it one of the most potent cannabinoid agonists identified to date.[1]

See also

References

  1. ^ Jiang S, Iliopoulos-Tsoutsouvas C, Tong F, Brust CA, Keenan CM, Raghav JG, et al. (April 2021). "Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists". Journal of Medicinal Chemistry. 64 (7): 3870–3884. doi:10.1021/acs.jmedchem.0c02053. PMID 33761251. S2CID 232355437.


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