Gepefrine

Today, Gepefrine is a topic of great relevance in our society. More and more people are interested in learning more about Gepefrine and its impact in different areas of life. From its importance in history to its influence on current trends, Gepefrine has become a topic of debate and reflection. In this article, we will explore the different aspects of Gepefrine and its connection with our daily lives, as well as its evolution over time. Through a deep and enriching analysis, we will discover the importance of Gepefrine and its role in our current world.

3-Hydroxyamphetamine
Clinical data
Trade namesPressionorm, Wintonin
Other names3-Hydroxyamphetamine; meta-Hydroxyamphetamine; α-Methyl-meta-tyramine; 3-Hydroxy-α-methylphenethylamine
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • (±)-3-(2-aminopropyl)phenol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
ECHA InfoCard100.012.779 Edit this at Wikidata
Chemical and physical data
FormulaC9H13NO
Molar mass151.209 g·mol−1
3D model (JSmol)
  • OC1=CC(C(C)N)=CC=C1
  • InChI=1S/C9H13NO/c1-7(10)5-8-3-2-4-9(11)6-8/h2-4,6-7,11H,5,10H2,1H3/t7-/m0/s1 checkY
  • Key:WTDGMHYYGNJEKQ-ZETCQYMHSA-N checkY
  (verify)

Gepefrine, also known as 3-hydroxyamphetamine or α-methyl-meta-tyramine and sold under the brand names Pressionorm and Wintonin, is a sympathomimetic medication used as an antihypotensive agent which has been marketed in Germany.[1][2][3][4]

Pharmacology

Gepefrine is described as a sympathomimetic and antihypotensive agent.[5]

Chemistry

Gepefrine, also known as 3-hydroxy-α-methylphenethylamine or as 3-hydroxyamphetamine, is a substituted phenethylamine and amphetamine derivative.[5] It is used pharmaceutically as the (S)-enantiomer and as the tartrate salt.[5][1] Related compounds include meta-tyramine (3-hydroxyphenethylamine), 4-hydroxyamphetamine (norpholedrine), 3,4-dihydroxyamphetamine (α-methyldopamine), and metaraminol ((1R,2S)-3,β-dihydroxyamphetamine), among others.

History

Gepefrine was synthesized by 1968[5] and was introduced for medical use in Germany by 1981.[3]

Society and culture

Names

Gepefrine is the generic name of the drug and its INNTooltip International Nonproprietary Name.[5] Brand names of gepefrine include Pressionorm and Wintonin.[1][6]

Other drugs

Gepefrine is a known metabolite of amphetamine in rats.[4]

References

  1. ^ a b c Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 487. ISBN 978-3-88763-075-1. Retrieved 24 April 2012.
  2. ^ Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 127. ISBN 978-0-412-46630-4. Retrieved 24 April 2012.
  3. ^ a b Publishing, W.A.W.A. (2013). Pharmaceutical Manufacturing Encyclopedia. Volumes 1-4. Elsevier Science. p. 1760. ISBN 978-0-8155-1856-3. Retrieved 2024-09-01.
  4. ^ a b Jonsson J (October 1977). "Identification of metahydroxyamphetamine as a metabolite of amphetamine in the rat". Research Communications in Chemical Pathology and Pharmacology. 18 (2): 189–199. PMID 918344.
  5. ^ a b c d e Elks, J. (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. pp. 73–74. ISBN 978-1-4757-2085-3. Retrieved 2024-09-01.
  6. ^ Challener, C.A. (2017). Chiral Drugs. Routledge Revivals. Taylor & Francis. p. 552. ISBN 978-1-351-80804-0. Retrieved 1 September 2024.