RU-24969

In today's world, RU-24969 is a topic that has gained relevance in different areas. Its impact has been felt in society, the economy, politics and culture. As RU-24969 has gained importance, there has been in-depth debate, research and analysis on its implications. From different perspectives and disciplines, answers, solutions and proposals are sought to address this issue effectively. In this article, we will explore various facets of RU-24969, examining its influence on the contemporary world and opening the door to reflections and discussions on its role in our present and future.

RU-24969
Clinical data
Other namesRU-24969; RU24969
Drug classSerotonin 5-HT1B and 5-HTA receptor agonist
Identifiers
  • 5-Methoxy-3-(1,2,5,6-tetrahydro-4-pyridinyl)-1H-indole
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC14H16N2O
Molar mass228.295 g·mol−1
3D model (JSmol)
  • c3cc(OC)cc1c3cc1C=2CCNCC=2
  • InChI=1S/C14H16N2O/c1-17-11-2-3-14-12(8-11)13(9-16-14)10-4-6-15-7-5-10/h2-4,8-9,15-16H,5-7H2,1H3 ☒N
  • Key:KRVMLPUDAOWOGN-UHFFFAOYSA-N ☒N
  (verify)

RU-24,969 is a serotonergic drug used in scientific research.[1][2] It is a selective agonist of the serotonin 5-HT1A and 5-HT1B receptors, with 5-fold preference for the latter receptor over the former.[1][2] It also has affinity for the serotonin 5-HT5A, 5-HT5B, and 5-HT7 receptors.[3]

The drug produces MDMA-like locomotor hyperactivity in animals and this is thought to be mediated by activation of both serotonin 5-HT1A and 5-HT1B receptors.[4][1][5][6][7] As with other serotonin 5-HT1B receptor agonists such as CP-94,253, RU-24,969 has also been found to increase the reinforcing properties of cocaine in animals, suggesting a role for serotonin 5-HT1B receptors in cocaine addiction as well.[8]

RU-24,969 was first described in the scientific literature by 1980.[9]

See also

References

  1. ^ a b c Martinez-Price D, Krebs-Thomson K, Geyer M (1 January 2002). "Behavioral Psychopharmacology of MDMA and MDMA-Like Drugs: A Review of Human and Animal Studies". Addiction Research & Theory. 10 (1). Informa UK Limited: 43–67. doi:10.1080/16066350290001704. ISSN 1606-6359.
  2. ^ a b Doods HN, Kalkman HO, De Jonge A, Thoolen MJ, Wilffert B, Timmermans PB, et al. (June 1985). "Differential selectivities of RU 24969 and 8-OH-DPAT for the purported 5-HT1A and 5-HT1B binding sites. Correlation between 5-HT1A affinity and hypotensive activity". European Journal of Pharmacology. 112 (3): 363–370. doi:10.1016/0014-2999(85)90782-4. PMID 3160596.
  3. ^ Grailhe R, Boschert U, Hen R (1997). "The 5-HT5, 5-HT6 and 5-HT7 receptors". Pharmacochemistry Library. Vol. 27. Elsevier. pp. 311–323. doi:10.1016/s0165-7208(97)80018-9. ISBN 978-0-444-82041-9. ISSN 0165-7208.
  4. ^ McDougall SA, Robinson JA, Ramirez EL, Diaz HA (February 2020). "Serotonin 5-HT1A and 5-HT1B receptors co-mediate the RU 24969-induced locomotor activity of male and female preweanling rats". Pharmacology, Biochemistry, and Behavior. 189: 172857. doi:10.1016/j.pbb.2020.172857. PMID 31958472.
  5. ^ Liechti ME, Vollenweider FX (December 2001). "Which neuroreceptors mediate the subjective effects of MDMA in humans? A summary of mechanistic studies". Human Psychopharmacology. 16 (8): 589–598. doi:10.1002/hup.348. PMID 12404538.
  6. ^ Rempel NL, Callaway CW, Geyer MA (May 1993). "Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release". Neuropsychopharmacology. 8 (3): 201–211. doi:10.1038/npp.1993.22. PMID 8099482.
  7. ^ Scearce-Levie K, Viswanathan SS, Hen R (January 1999). "Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT1B receptor". Psychopharmacology. 141 (2): 154–161. doi:10.1007/s002130050819. PMID 9952039.
  8. ^ Parsons LH, Weiss F, Koob GF (December 1998). "Serotonin1B receptor stimulation enhances cocaine reinforcement". The Journal of Neuroscience. 18 (23): 10078–10089. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMC 6793270. PMID 9822762.
  9. ^ Euvrard C, Boissier JR (April 1980). "Biochemical assessment of the central 5-HT agonist activity of RU 24969 (a piperidinyl indole)". European Journal of Pharmacology. 63 (1): 65–72. doi:10.1016/0014-2999(80)90117-x. PMID 6155275.
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