Nitroxazepine

In this article, we will explore the topic of Nitroxazepine in depth, examining its meaning, impact and relevance in today's society. From its origins to its current evolution, we will immerse ourselves in a detailed analysis that will allow us to understand the importance of Nitroxazepine in different areas of daily life. Through different perspectives and approaches, we will address its implications at both an individual and collective level, highlighting its influence in various sectors. Likewise, we will examine the role that Nitroxazepine plays in the current context, providing a comprehensive vision that will allow the reader to understand its importance and impact in the contemporary world.

Nitroxazepine
Chemical structure of Nitroxazepine
Clinical data
Trade namesSintamil
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 10--2-nitrodibenzooxazepin-11(10H)-one
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19N3O4
Molar mass341.367 g·mol−1
3D model (JSmol)
  • (=O)c2ccc1Oc3c(N(C(=O)c1c2)CCCN(C)C)cccc3
  • InChI=1S/C18H19N3O4/c1-19(2)10-5-11-20-15-6-3-4-7-17(15)25-16-9-8-13(21(23)24)12-14(16)18(20)22/h3-4,6-9,12H,5,10-11H2,1-2H3
  • Key:CGYWLLGTCBIGSR-UHFFFAOYSA-N

Nitroxazepine (brand name Sintamil) is a tricyclic antidepressant (TCA) which was introduced by Ciba-Geigy (now Novartis) for the treatment of depression in India in 1982.[1] It is also indicated for the treatment of nocturnal enuresis.[1] Nitroxazepine acts as a serotonin-norepinephrine reuptake inhibitor and has similar effects to imipramine, but with certain advantages, such as lower anticholinergic side effects.[2][3][4]

References

  1. ^ a b Progress in Medicinal Chemistry, Volume 22 (v. 22). Elsevier Science Publishing Company. 1985. p. 246. ISBN 0-444-80668-7.
  2. ^ Progress in Medicinal Chemistry, Volume 23 (v. 23). Not Avail. 2000. p. 136. ISBN 0-444-80802-7.
  3. ^ Ann Reports Medicinal Chem V11 (v. 11). Boston: Academic Press Inc. 1976. p. 4. ISBN 0-12-040511-3.
  4. ^ Johnson O, Jones DW, Nagarajan K, Bhadbhade MM, Venkatesan K (1992). "X-ray crystal structure analysis of nitroxazepine: 10-(3-dimethylaminopropyl)-2-nitro-10,11-dihydrodibenz oxazepin-11-one". Journal of Chemical Crystallography. 22 (5): 579–583. doi:10.1007/BF01161343. S2CID 96236391.


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