Metixene

Metixene is a topic that has generated great interest and debate in recent times. With multiple aspects, this issue has captured the attention of various sectors of society, from experts in the field to ordinary people interested in understanding its impact. As time progresses, Metixene positions itself as a central point in current conversations, provoking reflections and analysis from different perspectives. This article will seek to delve into the different facets of Metixene, exploring its implications and offering a complete overview of this topic.

Metixene
Clinical data
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Legal status
Identifiers
  • 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
CAS Number
PubChem CID
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CompTox Dashboard (EPA)
ECHA InfoCard100.023.282 Edit this at Wikidata
Chemical and physical data
FormulaC20H23NS
Molar mass309.47 g·mol−1
3D model (JSmol)
  • CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24
  • InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3
  • Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N
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Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent.[2] It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases. [3]

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Morton IK, Hall JM (1999). "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. p. 178. ISBN 978-94-011-4439-1.
  3. ^ Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. doi:10.1172/JCI161142. PMC 10721147. PMID 37847564. Retrieved 3 November 2023.



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