4-DAMP

This article will address the issue of 4-DAMP, which represents a very important issue today. From its origins to its relevance today, 4-DAMP has been the subject of debate and analysis in various areas. Throughout history, 4-DAMP has played a crucial role in society, directly or indirectly affecting the lives of millions of people around the world. In this sense, it is essential to understand in depth its impact and relevance, as well as the implications it entails for the present and the future. Through an exhaustive analysis, we seek to shed light on the different aspects related to 4-DAMP, providing the reader with a comprehensive and detailed vision of this very relevant topic.

4-DAMP
Names
Preferred IUPAC name
4--1,1-dimethylpiperidin-1-ium iodide
Other names
4-(2,2-Diphenylacetoxy)-1,1-dimethylpiperidin-1-ium iodide
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1
    Key: WWJHRSCUAQPFQO-UHFFFAOYSA-M
  • .C1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
Properties
C21H26INO2
Molar mass 451.348 g·mol−1
Appearance White to beige powder[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

4-DAMP (1,1-dimethyl-4-diphenylacetoxypiperidinium iodide) is a selective muscarinic acetylcholine receptor (mAChR) M3 antagonist.[2] It is also able to antagonize M1 receptors but has preferential activity at the M3 receptor.[3][4] It competitively binds to the acetylcholine binding site on mAChRs, causing right-ward shift in the dose response curves for mAChR agonists.

References

  1. ^ "4-DAMP". Sigma-Aldrich.
  2. ^ Zhu, MH; Sung, IK; Zheng, H; Sung, TS; Britton, FC; O'Driscoll, K; Koh, SD; Sanders, KM (2011). "Muscarinic activation of Ca2+-activated Cl- current in interstitial cells of Cajal". J Physiol. 589 (Pt18): 4565–4582. doi:10.1113/jphysiol.2011.211094. PMC 3208225. PMID 21768263.
  3. ^ Teixeira-Neto, FJ; McDonell, WN; Black, WD; Harris, W and; Grovum, L (2012). "Effects of muscarinic receptor antagonists on acetylcholine-induced contractions of jejunal smooth muscle in horses". Journal of Veterinary Pharmacology and Therapeutics. 35 (4): 313–318. doi:10.1111/j.1365-2885.2011.01330.x. PMID 21859432.
  4. ^ Greenwood, JM and; Dragunow, M (2010). "M3 muscarinic receptors promote cell survival through activation of the extracellular regulated kinase (ERK1/2) pathway". Eur J Pharmacol. 640 (1–3): 38–45. doi:10.1016/j.ejphar.2010.05.013. PMID 20519144.


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