Dexetimide

In this article, we will explore Dexetimide from different perspectives, delving into its importance, impact and relevance in today's society. Dexetimide is a topic that has captured the attention of experts and fans alike, and through this detailed analysis, we seek to shed light on its many facets. From its history to its future, through its implications in culture, politics and the economy, we will enter a universe of possibilities and challenges. Get ready to discover everything you need to know about Dexetimide and its influence on the modern world.

Dexetimide
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
Identifiers
  • 3-(1-benzyl-4-piperidyl)-3-phenylpiperidine-2,6-dione
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
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ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC23H26N2O2
Molar mass362.473 g·mol−1
3D model (JSmol)
  • O=C2NC(=O)CCC2(c1ccccc1)C4CCN(Cc3ccccc3)CC4
  • InChI=1S/C23H26N2O2/c26-21-11-14-23(22(27)24-21,19-9-5-2-6-10-19)20-12-15-25(16-13-20)17-18-7-3-1-4-8-18/h1-10,20H,11-17H2,(H,24,26,27)/t23-/m1/s1 checkY
  • Key:LQQIVYSCPWCSSD-HSZRJFAPSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dexetimide (brand name Tremblex) is a piperidine anticholinergic. It is a muscarinic antagonist that is used to treat drug induced parkinsonism. Dexetimide was discovered at Janssen Pharmaceutica in 1968.[2][3]

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Dom R, Van Lommel R, Baro F (1971). "A quantitative study of neuroleptic-induced extrapyramidal symptoms and their response to dexetimide, a potent and long-acting antiparkinsonian agent". Acta Psychiatrica Scandinavica. 47 (4): 399–410. doi:10.1111/j.1600-0447.1971.tb03697.x. PMID 4947805. S2CID 10591790.
  3. ^ Huygens H, Vereecken JL, Tanghe A (1973). "Dexetimide (R 16470) in the control of neuroleptic-induced extrapyramidal side-effects. Its prophylactic value and duration of action". Psychiatria, Neurologia, Neurochirurgia. 76 (4): 251–9. PMID 4581374.
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