Methdilazine

In today's world, Methdilazine has become a topic of great relevance and interest to a wide spectrum of people. Both professionally and personally, Methdilazine has generated debates and discussions about its impact and influence on society. From its origin to its current evolution, Methdilazine has been the subject of studies and research that have tried to shed light on its implications and consequences. In this article, we will explore some fundamental aspects of Methdilazine and analyze its role in different contexts. From its connection with technology, through its relationship with culture and politics, to its importance in everyday life, Methdilazine is a topic that continues to generate interest and reflection today.

Methdilazine
Clinical data
AHFS/Drugs.comMonograph
ATC code
Identifiers
  • 10-- 10H-phenothiazine
CAS Number
PubChem CID
IUPHAR/BPS
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ChEMBL
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ECHA InfoCard100.016.220 Edit this at Wikidata
Chemical and physical data
FormulaC18H20N2S
Molar mass296.43 g·mol−1
3D model (JSmol)
  • S2c1ccccc1N(c3c2cccc3)CC4CCN(C)C4
  • InChI=1S/C18H20N2S/c1-19-11-10-14(12-19)13-20-15-6-2-4-8-17(15)21-18-9-5-3-7-16(18)20/h2-9,14H,10-13H2,1H3 checkY
  • Key:HTMIBDQKFHUPSX-UHFFFAOYSA-N checkY
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Methdilazine (Dilosyn, Tacaryl) is a first-generation antihistamine with anticholinergic properties of the phenothiazine class.

Synthesis

Methdilazine synthesis:[1] R. F. Feldkamp and Y. H. Wu; Mead Johnson & Company; U.S. patent 2,945,855 (1960).

See also

References

  1. ^ L. W. Marsch and R. Peterson, Arzneimittel Forsch., 9, 715 (1959).
  • Rani Basu L, Mazumdar K, Dutta N, Karak P, Dastidar S (2005). "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine". Microbiol Res. 160 (1): 95–100. doi:10.1016/j.micres.2004.10.002. PMID 15782943.
  • Chattopadhyay D, Mukherjee T, Pal P, Saha B, Bhadra R (1998). "Altered membrane permeability as the basis of bactericidal action of methdilazine". J Antimicrob Chemother. 42 (1): 83–6. doi:10.1093/jac/42.1.83. PMID 9700532.
  • Chattopadhyay D, Dastidar S, Chakrabarty A (1988). "Antimicrobial properties of methdilazine and its synergism with antibiotics and some chemotherapeutic agents". Arzneimittelforschung. 38 (7): 869–72. PMID 2905130.

The ring-contracted analog, methdilazine shows only very weak activity as a tranquilizer; instead, that agent constitutes an important antihistamine.


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