Membrane steroid receptor
In today's article we are going to talk about Membrane steroid receptor, a topic that you have probably heard about, but that you may not know all the details about. Membrane steroid receptor is a topic that has aroused great interest in recent times, since its relevance and impact covers different areas. This is a topic that has been present throughout history, but is currently taking on special importance due to various factors. Throughout this article, we are going to delve into Membrane steroid receptor to better understand its meaning, its impact and its relevance in today's society. Read on to find out everything you need to know about Membrane steroid receptor!
Membrane steroid receptors (mSRs), also called extranuclear steroid receptors, are a class of cell surface receptors activated by endogenous steroids that mediate rapid, non-genomic signaling via modulation of intracellular signaling cascades.[1][2][3][4] mSRs are another means besides classical nuclear steroid hormone receptors (SHRs) for steroids to mediate their biological effects.[1][2][3][4] SHRs can produce slow genomic responses or rapid, non-genomic responses in the case of mSRs.[5]
List of membrane steroid receptors
Known groups of mSRs, by ligand, include:[a]
- Membrane sex steroid receptors
- Membrane corticosteroid receptors
- Membrane glucocorticoid receptors (mGRs) – caveolin-associated nuclear receptors; possible unidentified receptors[6]
- Membrane mineralocorticoid receptors (mMRs) – caveolin-associated NRs; diverse putative receptors[6]
In addition, PDIA3 is a membrane receptor for the secosteroid calcitriol, the activated form of Vitamin D.[8]
References
- ^ Semicolons roughly denote structural groups, e.g. G-protein receptors from ion channels.
- ^ a b Levin ER (June 2014). "Translating extranuclear steroid receptor signaling to clinical medicine". Hormones & Cancer. 5 (3): 140–145. doi:10.1007/s12672-014-0179-9. PMC 4040225. PMID 24752388.
- ^ a b Hammes SR, Levin ER (December 2011). "Minireview: Recent advances in extranuclear steroid receptor actions". Endocrinology. 152 (12): 4489–4495. doi:10.1210/en.2011-1470. PMC 3858720. PMID 22028449.
- ^ a b Sen A, Prizant H, Hammes SR (August 2011). "Understanding extranuclear (nongenomic) androgen signaling: what a frog oocyte can tell us about human biology". Steroids. 76 (9): 822–828. doi:10.1016/j.steroids.2011.02.016. PMC 4972037. PMID 21354434.
- ^ a b Watson CS (December 1999). "Signaling themes shared between peptide and steroid hormones at the plasma membrane". Science's STKE. 1999 (12): PE1. doi:10.1126/stke.1999.12.pe1. PMC 1317563. PMID 11865187.
- ^ Norman AW, Mizwicki MT, Norman DP (January 2004). "Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model". Nature Reviews. Drug Discovery. 3 (1): 27–41. doi:10.1038/nrd1283. PMID 14708019. S2CID 17487277.
- ^ a b c d e f g Treviño LS, Gorelick DA (August 2021). "The Interface of Nuclear and Membrane Steroid Signaling". Endocrinology. 162 (8): bqab107. doi:10.1210/endocr/bqab107. PMC 8214340. PMID 34038515.
- ^ Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, et al. (January 2025). "Identification, structure, and agonist design of an androgen membrane receptor". Cell. doi:10.1016/j.cell.2025.01.006. PMID 39884271.
- ^ Gaucci E, Raimondo D, Grillo C, Cervoni L, Altieri F, Nittari G, et al. (November 2016). "Analysis of the interaction of calcitriol with the disulfide isomerase ERp57". Scientific Reports. 6: 37957. Bibcode:2016NatSR...637957G. doi:10.1038/srep37957. PMC 5126700. PMID 27897272.
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