Retinoic acid-inducible orphan G protein-coupled receptor

In today's article we are going to delve into the topic of Retinoic acid-inducible orphan G protein-coupled receptor, an aspect that has been debated for a long time. Retinoic acid-inducible orphan G protein-coupled receptor is a topic that has generated great interest among experts and fans alike, and is crucial to understanding its impact on different aspects of modern society. Throughout this article, we will analyze the different approaches that have been taken in relation to Retinoic acid-inducible orphan G protein-coupled receptor, as well as their implications on a personal, social and global level. Additionally, we will explore some of the most recent research on Retinoic acid-inducible orphan G protein-coupled receptor and discuss possible implications for the future. Ultimately, this article aims to offer a complete and updated view on Retinoic acid-inducible orphan G protein-coupled receptor, with the aim of providing our readers with a deeper understanding of this very relevant topic.

G protein-coupled receptor, family C, group 5, member A
Identifiers
SymbolGPRC5A
Alt. symbolsRAIG1, RAI3
NCBI gene9052
HGNC9836
OMIM604138
RefSeqNM_003979
UniProtQ8NFJ5
Other data
LocusChr. 12 p13-p12.3
Search for
StructuresSwiss-model
DomainsInterPro
G protein coupled receptor, family C, group 5, member B
Identifiers
SymbolGPRC5B
Alt. symbolsRAIG2
NCBI gene51704
HGNC13308
OMIM605948
RefSeqNM_016235
UniProtQ9NZH0
Other data
LocusChr. 16 p12
Search for
StructuresSwiss-model
DomainsInterPro
G protein-coupled receptor, family C, group 5, member C
Identifiers
SymbolGPRC5C
Alt. symbolsRAIG3
NCBI gene55890
HGNC13309
OMIM605949
RefSeqNM_022036
UniProtQ9NQ84
Other data
LocusChr. 17 q25
Search for
StructuresSwiss-model
DomainsInterPro
G protein-coupled receptor, family C, group 5, member D
Identifiers
SymbolGPRC5D
NCBI gene55507
HGNC13310
OMIM607437
RefSeqNM_018654
UniProtQ9NZD1
Other data
LocusChr. 12 p13.3
Search for
StructuresSwiss-model
DomainsInterPro

The Retinoic Acid-Inducible orphan G-protein-coupled receptors (RAIG) are a group of four closely related G protein-coupled receptors whose expression is induced by retinoic acid.[1][2][3][4]

The exact function of these proteins has not been determined but they may provide a mechanism by which retinoic acid can influence G protein signal transduction cascades. In addition, RAIG receptors interact with members of the frizzled class of G protein-coupled receptors and appear to activate the Wnt signaling pathway.[5]

References

  1. ^ Cheng Y, Lotan R (1998). "Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor". J. Biol. Chem. 273 (52): 35008–15. doi:10.1074/jbc.273.52.35008. PMID 9857033.
  2. ^ Bräuner-Osborne H, Krogsgaard-Larsen P (2000). "Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain". Genomics. 65 (2): 121–8. doi:10.1006/geno.2000.6164. PMID 10783259.
  3. ^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN (2000). "Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C)". Genomics. 67 (1): 8–18. doi:10.1006/geno.2000.6226. PMID 10945465.
  4. ^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P (2001). "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochim. Biophys. Acta. 1518 (3): 237–48. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
  5. ^ Harada Y, Yokota C, Habas R, Slusarski DC, He X (2007). "Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling". Biochem. Biophys. Res. Commun. 358 (4): 968–75. doi:10.1016/j.bbrc.2007.04.208. PMC 2854581. PMID 17521608.
Stub icon

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.