TAS2R3

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Protein-coding gene in the species Homo sapiens

TAS2R3
Identifiers
Aliases	TAS2R3, T2R3, taste 2 receptor member 3
External IDs	OMIM: 604868; MGI: 3606604; HomoloGene: 23231; GeneCards: TAS2R3; OMA:TAS2R3 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 141,764,097 bp[1] End 141,765,197 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 40,468,167 bp[2] End 40,469,239 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum epithelium of colon Achilles tendon tonsil right hemisphere of cerebellum right uterine tube urinary bladder ovary body of uterus muscle of thigh Top expressed in embryo primary oocyte zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity taste receptor activity bitter taste receptor activity Cellular component plasma membrane membrane integral component of membrane Biological process detection of chemical stimulus involved in sensory perception of bitter taste sensory perception of taste signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 50831 574417 Ensembl ENSG00000127362 ENSMUSG00000052850 UniProt Q9NYW6 Q7TQA7 RefSeq (mRNA) NM_016943 NM_001025385 RefSeq (protein) NP_058639 NP_001020556 Location (UCSC) Chr 7: 141.76 – 141.77 Mb Chr 6: 40.47 – 40.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Taste receptor type 2 member 3 is a protein that in humans is encoded by the TAS2R3 gene.^[5]

Function

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception.^[5]

Ligands

The only known ligand for TAS2R3 in BitterDB is chloroquine.^[6]

See also

• Taste receptor

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000127362 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000052850 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b} "Entrez Gene: TAS2R3 taste receptor, type 2, member 3".
6. ^ "hTAS2R3". BitterDB. The Hebrew University of Jerusalem.

Further reading

• Kinnamon SC (2000). "A plethora of taste receptors". Neuron. 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
• Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
• Montmayeur JP, Matsunami H (2002). "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982. S2CID 37807140.
• Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). "A novel family of mammalian taste receptors". Cell. 100 (6): 693–702. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934. S2CID 14604586.
• Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000). "T2Rs function as bitter taste receptors". Cell. 100 (6): 703–11. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935. S2CID 7293493.
• Firestein S (2000). "The good taste of genomics". Nature. 404 (6778): 552–3. doi:10.1038/35007167. PMID 10766221. S2CID 35741332.
• Matsunami H, Montmayeur JP, Buck LB (2000). "A family of candidate taste receptors in human and mouse". Nature. 404 (6778): 601–4. Bibcode:2000Natur.404..601M. doi:10.1038/35007072. PMID 10766242. S2CID 4336913.
• Ueda T, Ugawa S, Ishida Y, Shibata Y, Murakami S, Shimada S (2001). "Identification of coding single-nucleotide polymorphisms in human taste receptor genes involving bitter tasting". Biochem. Biophys. Res. Commun. 285 (1): 147–51. doi:10.1006/bbrc.2001.5136. PMID 11437385.
• Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ (2003). "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell. 112 (3): 293–301. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520. S2CID 718601.
• Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
• Go Y, Satta Y, Takenaka O, Takahata N (2006). "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

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