GPR174

In this article we will explore GPR174, a topic that has captured the attention and interest of many people today. GPR174 is a topic that covers a wide range of aspects and has a significant impact on various areas of life. As we progress through this article, we will explore the different facets of GPR174 and examine its relevance in contemporary society. Additionally, we will dive into the different perspectives and opinions that exist around GPR174, offering a complete and balanced view of this topic. Without a doubt, GPR174 is a topic that deserves our attention and detailed analysis, so we will delve into its complexity and depth throughout this article.

Protein-coding gene in humans

GPR174
Identifiers
Aliases	GPR174, GPCR17, LYPSR3, FKSG79, G protein-coupled receptor 174
External IDs	OMIM: 300903; MGI: 2685222; HomoloGene: 13059; GeneCards: GPR174; OMA:GPR174 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq21.1 Start 79,144,688 bp[1] End 79,175,318 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X D Start 106,299,484 bp[2] End 106,340,375 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus mucosa of ileum lymph node granulocyte appendix epithelium of nasopharynx epithelium of colon spleen superficial temporal artery blood Top expressed in spleen mesenteric lymph nodes blood thymus lumbar spinal ganglion subcutaneous adipose tissue lumbar subsegment of spinal cord granulocyte white adipose tissue dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity bioactive lipid receptor activity Cellular component integral component of membrane plasma membrane membrane integral component of plasma membrane Biological process signal transduction G protein-coupled receptor signaling pathway positive regulation of Rho protein signal transduction T cell homeostasis positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84636 213439 Ensembl ENSG00000147138 ENSMUSG00000073008 UniProt Q9BXC1 Q3U507 RefSeq (mRNA) NM_032553 NM_001033251 NM_001177781 NM_001177782 NM_001358747 RefSeq (protein) NP_115942 NP_001028423 NP_001171252 NP_001171253 NP_001345676 Location (UCSC) Chr X: 79.14 – 79.18 Mb Chr X: 106.3 – 106.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 174 is a protein that in humans is encoded by the GPR174 gene.^[5] The receptor has been reported to bind to lysophosphatidylserine. ^[6][7]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000147138 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000073008 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: GPR174 G protein-coupled receptor 174".
6. ^ Liu G, Li X, Wang Y, Zhang X, Gong W (2023). "Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174". PLOS Biol. 21 (12): e3002387. doi:10.1371/journal.pbio.3002387. PMC 10721165. PMID 38048360.{{cite journal}}: CS1 maint: multiple names: authors list (link)
7. ^ Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y; et al. (2023). "Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive Gs signaling". Nat Commun. 14 (1): 5901. doi:10.1038/s41467-023-41654-3. PMC 10516915. PMID 37737235.{{cite journal}}: CS1 maint: multiple names: authors list (link)

Further reading

• Takeda S, Kadowaki S, Haga T, et al. (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. Bibcode:2002FEBSL.520...97T. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.

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