GPR114

Nowadays, GPR114 is a topic that has gained more and more relevance in our society. Whether due to its impact on people's daily lives, its influence on popular culture or its importance in the professional field, GPR114 has proven to be a topic of general interest. As time progresses, GPR114 continues to evolve and present new challenges, opportunities and questions for those who wish to delve into its study. In this article, we will explore some key aspects of GPR114 and its impact on different aspects of our lives, as well as its relevance today.

ADGRG5
Identifiers
AliasesADGRG5, PGR27, GPR114, adhesion G protein-coupled receptor G5
External IDsOMIM: 616965; MGI: 2685955; HomoloGene: 17828; GeneCards: ADGRG5; OMA:ADGRG5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

221188

382045

Ensembl

ENSG00000159618

ENSMUSG00000061577

UniProt

Q8IZF4

Q3V3Z3

RefSeq (mRNA)

NM_001304376
NM_153837
NM_001318481

NM_001033468
NM_001145972

RefSeq (protein)

NP_001291305
NP_001305410
NP_722579

NP_001028640
NP_001139444

Location (UCSC)Chr 16: 57.54 – 57.59 MbChr 8: 95.65 – 95.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G protein-coupled receptor 114 is a protein encoded by the ADGRG5 gene.[5][6][7] GPR114 is a member of the adhesion GPCR family.[8][9] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[10]

Tissue distribution

GPR114 mRNA is specifically expressed in human eosinophils as well as in mouse lymphocytes, monocytes, macrophage, and dendritic cells.[11]

Signaling

The cyclic adenosine monophosphate (cAMP) assay in overexpressing HEK293 cells has demonstrated coupling of GPR114 to Gαs protein.[12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000159618 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061577 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: GPR114 G protein-coupled receptor 114".
  6. ^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (November 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–414. Bibcode:2002FEBSL.531..407F. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
  7. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  8. ^ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
  9. ^ Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
  10. ^ Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
  11. ^ Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (Apr 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
  12. ^ Gupte J, Swaminath G, Danao J, Tian H, Li Y, Wu X (April 2012). "Signaling property study of adhesion G-protein-coupled receptors". FEBS Letters. 586 (8): 1214–1219. Bibcode:2012FEBSL.586.1214G. doi:10.1016/j.febslet.2012.03.014. PMID 22575658. S2CID 3020230.