GPR63

In this article we will explore the topic of GPR63 from various perspectives, covering its historical, cultural, social and emotional implications. GPR63 is a topic of great relevance today, which has sparked interest and debate in different areas. Throughout the article we will analyze the different aspects of GPR63, delving into its meaning, impact and possible solutions. Through a multidisciplinary approach, we seek to provide a comprehensive look that allows the reader to understand the complexity and importance of GPR63 in the contemporary context.

Protein-coding gene in the species Homo sapiens

GPR63
Identifiers
Aliases	GPR63, PSP24(beta), PSP24B, G protein-coupled receptor 63
External IDs	OMIM: 606915; MGI: 2135884; HomoloGene: 12759; GeneCards: GPR63; OMA:GPR63 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.1 Start 96,794,125 bp[1] End 96,837,477 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A3 Start 24,966,407 bp[2] End 25,009,233 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle ventricular zone ganglionic eminence popliteal artery tibial arteries prefrontal cortex right coronary artery rectum left coronary artery Top expressed in secondary oocyte zygote tail of embryo dentate gyrus of hippocampal formation granule cell primary visual cortex ventricular zone superior frontal gyrus embryo cerebellar cortex genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity molecular function Cellular component integral component of membrane receptor complex membrane nucleus cytosol plasma membrane Biological process G protein-coupled receptor signaling pathway signal transduction biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81491 81006 Ensembl ENSG00000112218 ENSMUSG00000040372 UniProt Q9BZJ6 Q9EQQ3 RefSeq (mRNA) NM_001143957 NM_030784 NM_030733 NM_001379626 NM_001379627 RefSeq (protein) NP_001137429 NP_110411 NP_109658 NP_001366555 NP_001366556 Location (UCSC) Chr 6: 96.79 – 96.84 Mb Chr 4: 24.97 – 25.01 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable G-protein coupled receptor 63 is a protein that in humans is encoded by the GPR63 gene.^[5]

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.^[5]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000112218 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000040372 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b} "Entrez Gene: GPR63 G protein-coupled receptor 63".

Further reading

• Kawasawa Y, Kume K, Nakade S, et al. (2000). "Brain-specific expression of novel G-protein-coupled receptors, with homologies to Xenopus PSP24 and human GPR45". Biochem. Biophys. Res. Commun. 276 (3): 952–6. doi:10.1006/bbrc.2000.3569. PMID 11027574.
• Kawasawa Y, Kume K, Izumi T, Shimizu T (2000). "Mammalian PSP24s (alpha and beta isoforms) are not responsive to lysophosphatidic acid in mammalian expression systems". Biochem. Biophys. Res. Commun. 276 (3): 957–64. doi:10.1006/bbrc.2000.3570. PMID 11027575.
• Lee DK, George SR, Cheng R, et al. (2001). "Identification of four novel human G protein-coupled receptors expressed in the brain". Brain Res. Mol. Brain Res. 86 (1–2): 13–22. doi:10.1016/S0169-328X(00)00242-4. PMID 11165367.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Niedernberg A, Tunaru S, Blaukat A, et al. (2004). "Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63". Cell. Signal. 15 (4): 435–46. CiteSeerX 10.1.1.486.4056. doi:10.1016/S0898-6568(02)00119-5. PMID 12618218.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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