ZNF281

Since time immemorial, ZNF281 has been the subject of fascination, study and debate. Its impact has transcended all cultural, geographical and temporal barriers, leaving an indelible mark on the history of humanity. From the remotest reaches of the past to the most immediate present, ZNF281 has been an object of adoration, analysis, and contemplation. In this article, we will explore in depth the many facets of ZNF281, unraveling its meaning, its influence and its relevance in today's world. Throughout the pages that follow, we will embark on a fascinating journey through history, science, culture and society, in search of a more complete and enriching understanding of ZNF281.

Protein-coding gene in the species Homo sapiens

ZNF281
Identifiers
Aliases	ZNF281, ZBP-99, ZNP-99, zinc finger protein 281, ZBP99, GZP1
External IDs	MGI: 3029290; HomoloGene: 8270; GeneCards: ZNF281; OMA:ZNF281 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q32.1 Start 200,404,940 bp[1] End 200,410,056 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E4 Start 136,552,639 bp[2] End 136,557,791 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte endothelial cell cerebellar vermis Brodmann area 23 trabecular bone buccal mucosa cell inferior ganglion of vagus nerve visceral pleura Skeletal muscle tissue of rectus abdominis germinal epithelium Top expressed in olfactory tubercle mandibular prominence ascending aorta maxillary prominence superior cervical ganglion hand aortic valve medial geniculate nucleus lateral septal nucleus substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding transcription corepressor activity DNA-binding transcription factor activity metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process cell differentiation regulation of transcription, DNA-templated embryonic body morphogenesis negative regulation of transcription by RNA polymerase II negative regulation of gene expression transcription, DNA-templated stem cell differentiation positive regulation of transcription, DNA-templated negative regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23528 226442 Ensembl ENSG00000162702 ENSMUSG00000041483 UniProt Q9Y2X9 Q99LI5 RefSeq (mRNA) NM_012482 NM_001281293 NM_001281294 NM_001160251 NM_177643 RefSeq (protein) NP_001268222 NP_001268223 NP_036614 NP_001153723 NP_808311 Location (UCSC) Chr 1: 200.4 – 200.41 Mb Chr 1: 136.55 – 136.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 281 is a protein that in humans is encoded by the ZNF281 gene.^[5][6]

See also

• Zinc finger

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000162702 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000041483 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Law DJ, Du M, Law GL, Merchant JL (Sep 1999). "ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression". Biochem Biophys Res Commun. 262 (1): 113–120. doi:10.1006/bbrc.1999.1180. PMID 10448078.
6. ^ "Entrez Gene: ZNF281 zinc finger protein 281".

Further reading

• Lisowsky T, Polosa PL, Sagliano A, et al. (1999). "Identification of human GC-box-binding zinc finger protein, a new Krüppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence". FEBS Lett. 453 (3): 369–374. Bibcode:1999FEBSL.453..369L. doi:10.1016/S0014-5793(99)00754-1. PMID 10405178. S2CID 33226036.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• ZNF281+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

• v
• t
• e