PHF20

This article will address PHF20, a topic that has captivated the interest of numerous scholars and specialists in different areas of knowledge. The relevance of PHF20 is manifested through its impact on society, culture, history and human development. Over time, PHF20 has sparked debates, research and reflections that have enriched the understanding of this phenomenon. From various perspectives and approaches, the multiple facets of PHF20 have been analyzed, revealing its complexity and its influence on various aspects of daily life. In this sense, this article aims to explore the phenomenon of PHF20 in a comprehensive and rigorous manner, providing a broad and updated vision of this topic.

Protein-coding gene in the species Homo sapiens

PHF20
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3P8D, 3Q1J, 3QII, 3SD4
Identifiers
Aliases	PHF20, C20orf104, GLEA2, HCA58, NZF, TDRD20A, TZP, PHD finger protein 20
External IDs	OMIM: 610335; MGI: 2444148; HomoloGene: 9507; GeneCards: PHF20; OMA:PHF20 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.22-q11.23 Start 35,771,974 bp[1] End 35,950,370 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H1 Start 156,196,466 bp[2] End 156,309,952 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell sperm epithelium of colon Achilles tendon Brodmann area 23 germinal epithelium amniotic fluid glutes visceral pleura parietal pleura Top expressed in zygote ectoderm otic placode otic vesicle saccule primary oocyte secondary oocyte Region I of hippocampus proper cerebellar vermis lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone acetyltransferase activity (H4-K8 specific) DNA binding histone acetyltransferase activity (H4-K5 specific) metal ion binding histone acetyltransferase activity (H4-K16 specific) protein binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nuclear membrane histone acetyltransferase complex nucleus nucleoplasm cytosol MLL1 complex Biological process histone H4-K16 acetylation regulation of transcription, DNA-templated transcription, DNA-templated histone H4-K5 acetylation histone H4-K8 acetylation regulation of signal transduction by p53 class mediator chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51230 228829 Ensembl ENSG00000025293 ENSMUSG00000038116 UniProt Q9BVI0 Q5JWZ0 Q8BLG0 RefSeq (mRNA) NM_016436 NM_172674 RefSeq (protein) NP_057520 NP_766262 Location (UCSC) Chr 20: 35.77 – 35.95 Mb Chr 2: 156.2 – 156.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PHD finger protein 20 is a protein that in humans is encoded by the PHF20 gene.^[5]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000025293 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000038116 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "Entrez Gene: PHF20 PHD finger protein 20".

Further reading

• Fischer U, Struss AK, Hemmer D, Pallasch CP, Steudel WI, Meese E (November 2001). "Glioma-expressed antigen 2 (GLEA2): a novel protein that can elicit immune responses in glioblastoma patients and some controls". Clin. Exp. Immunol. 126 (2): 206–13. doi:10.1046/j.1365-2249.2001.01635.x. PMC 1906187. PMID 11703362.
• Behrends U, Schneider I, Rössler S, Frauenknecht H, Golbeck A, Lechner B, Eigenstetter G, Zobywalski C, Müller-Weihrich S, Graubner U, Schmid I, Sackerer D, Späth M, Goetz C, Prantl F, Asmuss HP, Bise K, Mautner J (August 2003). "Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries". Int. J. Cancer. 106 (2): 244–51. doi:10.1002/ijc.11208. PMID 12800201. S2CID 36836051.
• Pallasch CP, Struss AK, Munnia A, König J, Steudel WI, Fischer U, Meese E (November 2005). "Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival". Int. J. Cancer. 117 (3): 456–9. doi:10.1002/ijc.20929. PMID 15906353. S2CID 32083805.
• Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G (August 2012). "PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53". Nat. Struct. Mol. Biol. 19 (9): 916–24. doi:10.1038/nsmb.2353. PMC 3454513. PMID 22864287.

External links

• PHF20+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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