PHF3

Today we want to talk about PHF3, a topic that has captured the attention of millions in recent years. PHF3 is a topic that has generated debate, inspired change, and challenged established norms. Since its emergence, PHF3 has generated interest and curiosity, it has become a source of inspiration and a reason for reflection. Throughout history, PHF3 has played a crucial role in culture, society, and people's lives. In this article, we will explore different aspects of PHF3, from its impact on society to its implications in today's world.

Protein-coding gene in the species Homo sapiens

PHF3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DME
Identifiers
Aliases	PHF3, PHD finger protein 3
External IDs	OMIM: 607789; MGI: 2446126; HomoloGene: 9040; GeneCards: PHF3; OMA:PHF3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q12 Start 63,635,802 bp[1] End 63,779,336 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 A5- B Start 30,841,420 bp[2] End 30,913,002 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii Achilles tendon germinal epithelium tibia endothelial cell parietal pleura internal globus pallidus visceral pleura corpus callosum palpebral conjunctiva Top expressed in secondary oocyte zygote tail of embryo primary oocyte genital tubercle neural layer of retina renal corpuscle left lung lobe cumulus cell mesenteric lymph nodes More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding molecular function Cellular component cellular component Biological process multicellular organism development transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23469 213109 Ensembl ENSG00000118482 ENSMUSG00000048874 UniProt Q92576 n/a RefSeq (mRNA) NM_001290259 NM_001290260 NM_015153 NM_001370348 NM_001370349 NM_001370350 NM_001081080 NM_025871 RefSeq (protein) NP_001277188 NP_001277189 NP_055968 NP_001357277 NP_001357278 NP_001357279 n/a Location (UCSC) Chr 6: 63.64 – 63.78 Mb Chr 1: 30.84 – 30.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PHD finger protein 3 is a protein that in humans is encoded by the PHF3 gene.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000118482 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000048874 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Fischer U, Struss AK, Hemmer D, Michel A, Henn W, Steudel WI, Meese E (Mar 2002). "PHF3 expression is frequently reduced in glioma". Cytogenet Cell Genet. 94 (3–4): 131–6. doi:10.1159/000048804. PMID 11856869. S2CID 44396216.
6. ^ "Entrez Gene: PHF3 PHD finger protein 3".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Struss AK, Romeike BF, Munnia A, et al. (2001). "PHF3-specific antibody responses in over 60% of patients with glioblastoma multiforme". Oncogene. 20 (31): 4107–14. doi:10.1038/sj.onc.1204552. PMID 11464277.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pallasch CP, Struss AK, Munnia A, et al. (2005). "Autoantibodies against GLEA2 and PHF3 in glioblastoma: tumor-associated autoantibodies correlated with prolonged survival". Int. J. Cancer. 117 (3): 456–9. doi:10.1002/ijc.20929. PMID 15906353. S2CID 32083805.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• PHF3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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