Evx1

In this article, we will thoroughly explore the topic of Evx1, a topic that has captured the attention of people of all ages and walks of life. From its importance in history to its relevance today, Evx1 has been the subject of study and interest for researchers, academics and enthusiasts alike. Through a comprehensive analysis, we will examine the various aspects related to Evx1, from its origins to its impact on modern society. With the intention of providing a complete and detailed overview of Evx1, this article will delve into its many facets, offering a broad and enriching perspective to understand its true meaning and scope.

Evx1 is a mammalian gene located downstream of the HoxA cluster, which encodes for a homeobox transcription factor. Evx1 is a homolog of even-skipped (eve), which is a pair-rule gene that regulates body segmentation in Drosophila.[1][2] The expression of Evx1 is developmentally regulated, displaying a biphasic expression pattern with peak expression in the primitive streak during gastrulation and in interneurons during neural development.[3][4] Evx1 has been shown to regulate anterior-posterior patterning during gastrulation by acting as a downstream effector of the Wnt and BMP signalling pathways.[4][5] It is also a critical regulator of interneuron identity.[6]

Despite a regulatory role in both of these processes, the Evx1 KO mouse is viable and displays no overt phenotype after birth.[4][6]

A divergent long non-coding RNA (Evx1as) is also expressed from the locus, which is temporally and spatially co-expressed with Evx1.[3][4][7] Evx1as does not have a function beyond that of Evx1 (in trans);[4] however, it has been shown to regulate Evx1 at the locus (in cis).[7]

References

  1. ^ Nüsslein-Volhard, Christiane; Wieschaus, Eric (1980-10-30). "Mutations affecting segment number and polarity in Drosophila". Nature. 287 (5785): 795–801. Bibcode:1980Natur.287..795N. doi:10.1038/287795a0. PMID 6776413. S2CID 4337658.
  2. ^ Manoukian, A. S.; Krause, H. M. (1992-09-01). "Concentration-dependent activities of the even-skipped protein in Drosophila embryos". Genes & Development. 6 (9): 1740–1751. doi:10.1101/gad.6.9.1740. ISSN 0890-9369. PMID 1355458.
  3. ^ a b Dinger, Marcel E.; Amaral, Paulo P.; Mercer, Tim R.; Pang, Ken C.; Bruce, Stephen J.; Gardiner, Brooke B.; Askarian-Amiri, Marjan E.; Ru, Kelin; Soldà, Giulia (2008-09-01). "Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation". Genome Research. 18 (9): 1433–1445. doi:10.1101/gr.078378.108. ISSN 1088-9051. PMC 2527704. PMID 18562676.
  4. ^ a b c d e Bell, Charles C.; Amaral, Paulo P.; Kalsbeek, Anton; Magor, Graham W.; Gillinder, Kevin R.; Tangermann, Pierre; Lisio, Lorena di; Cheetham, Seth W.; Gruhl, Franziska (2016-05-26). "The Evx1/Evx1as gene locus regulates anterior-posterior patterning during gastrulation". Scientific Reports. 6: 26657. Bibcode:2016NatSR...626657B. doi:10.1038/srep26657. ISSN 2045-2322. PMC 4880930. PMID 27226347.
  5. ^ Kalisz, Mark; Winzi, Maria; Bisgaard, Hanne Cathrine; Serup, Palle (2012-02-01). "EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression". Developmental Biology. 362 (1): 94–103. doi:10.1016/j.ydbio.2011.11.017. PMID 22178155.
  6. ^ a b Moran-Rivard, Laura; Kagawa, Tetsushi; Saueressig, Harald; Gross, Michael K.; Burrill, John; Goulding, Martyn (2001-02-01). "Evx1 Is a Postmitotic Determinant of V0 Interneuron Identity in the Spinal Cord". Neuron. 29 (2): 385–399. doi:10.1016/S0896-6273(01)00213-6. ISSN 0896-6273. PMID 11239430.
  7. ^ a b Luo, Sai; Lu, J. Yuyang; Liu, Lichao; Yin, Yafei; Chen, Chunyan; Han, Xue; Wu, Bohou; Xu, Ronggang; Liu, Wei (2016-05-05). "Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells". Cell Stem Cell. 18 (5): 637–652. doi:10.1016/j.stem.2016.01.024. ISSN 1934-5909. PMID 26996597.