FOXO6

Today, in this article, we are going to talk about FOXO6. FOXO6 is a topic that has sparked the interest and curiosity of many people over the years. Whether for its relevance in today's society, its impact on history, its potential for the future, or simply for its emotional value, FOXO6 is a topic that deserves to be analyzed and discussed. Throughout this article, we will explore different aspects of FOXO6, from its origin and evolution to its influence on various areas of life. We hope this reading is informative and enriching for all those seeking a greater understanding of FOXO6.

FOXO6
Identifiers
AliasesFOXO6, forkhead box O6
External IDsOMIM: 611457; MGI: 2676586; HomoloGene: 82395; GeneCards: FOXO6; OMA:FOXO6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291281

NM_194060

RefSeq (protein)

NP_001278210

NP_918949

Location (UCSC)Chr 1: 41.36 – 41.38 MbChr 4: 120.12 – 120.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[5]

FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[6]

References

  1. ^ a b c ENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052135Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Forkhead box O6".
  6. ^ a b c Lee S, Dong HH (2017). "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology. 233 (2): R67 – R79. doi:10.1530/JOE-17-0002. PMC 5480241. PMID 28213398.

Further reading