TRIMU 5

Today, TRIMU 5 continues to be a topic of great interest and relevance in today's society. Whether due to its impact on people's daily lives, its influence on popular culture or its importance in academia and science, TRIMU 5 continues to be the subject of constant analysis and debate. In this article, we will explore different aspects related to TRIMU 5, from its history and evolution to its current state and possible future developments. Through this analysis, we hope to shed light on the importance and relevance of TRIMU 5 today and its impact on different aspects of society.

TRIMU 5
Names
IUPAC name
L-Tyrosyl-N-{acetyl}-D-alaninamide
Systematic IUPAC name
(2R)-2-Amino-3-(4-hydroxyphenyl)-N-acetamido}-1-oxopropan-2-yl]propanamide
Identifiers
3D model (JSmol)
ChemSpider
  • InChI=1S/C19H30N4O4/c1-12(2)8-9-21-11-17(25)23-18(26)13(3)22-19(27)16(20)10-14-4-6-15(24)7-5-14/h4-7,12-13,16,21,24H,8-11,20H2,1-3H3,(H,22,27)(H,23,25,26)/t13-,16?/m1/s1 checkY
    Key: QOGVSHVPIMZZRN-JBZHPUCOSA-N checkY
  • InChI=1/C19H30N4O4/c1-12(2)8-9-21-11-17(25)23-18(26)13(3)22-19(27)16(20)10-14-4-6-15(24)7-5-14/h4-7,12-13,16,21,24H,8-11,20H2,1-3H3,(H,22,27)(H,23,25,26)/t13-,16?/m1/s1
    Key: QOGVSHVPIMZZRN-JBZHPUCOBN
  • Oc1ccc(C(N)C(=O)N(C)C(=O)NC(=O)CNCCC(C)C)cc1
Properties
C19H30N4O4
Molar mass 378.466
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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TRIMU-5 is a selective agonist of the μ2-opioid receptor and antagonist of the μ1-opioid receptor.[1][2] It produces analgesia in animals that differs from that of conventional μ-opioid receptor agonists but that can still be blocked by μ-opioid receptor antagonists.[1] TRIMU-5 can also block the analgesic effects of μ-opioid receptor agonists like morphine.[1] In addition to analgesia, TRIMU-5 inhibits gastrointestinal transit, a known effect of μ2-opioid receptor activation.[1]

References

  1. ^ a b c d Tive LA, Pick CG, Paul D, Roques BP, Gacel GA, Pasternak GW (June 1992). "Analgesic potency of TRIMU-5: a mixed mu 2 opioid receptor agonist/mu 1 opioid receptor antagonist". Eur J Pharmacol. 216 (2): 249–55. doi:10.1016/0014-2999(92)90367-d. PMID 1327812.
  2. ^ Eisenberg RM (1994). "TRIMU-5, a mu 2-opioid receptor agonist, stimulates the hypothalamo-pituitary-adrenal axis". Pharmacol. Biochem. Behav. 47 (4): 943–6. doi:10.1016/0091-3057(94)90300-X. PMID 8029266. S2CID 54354971.


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