RWJ-394674

In today's world, RWJ-394674 is a topic that is constantly evolving and that arouses great interest in society. Whether due to its historical relevance, its impact on popular culture or its influence on everyday life, RWJ-394674 has managed to capture the attention of people of all ages and backgrounds. In this article, we will explore in detail the different aspects related to RWJ-394674, from its origin to its present day, analyzing its importance and impact on various aspects of modern life. Additionally, we will examine the role RWJ-394674 plays in today's society and how it has influenced the way we think and act. Through in-depth and comprehensive analysis, we will be in a position to better understand the importance of RWJ-394674 and its impact on the world around us.

RWJ-394674
Legal status
Legal status
  • In general: legal
Identifiers
  • N,N-diethyl-4-((8-phenethyl-8-azabicyclooct-3-ylidene)phenylmethyl)benzamide
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC33H38N2O
Molar mass478.680 g·mol−1
3D model (JSmol)
  • CCN(CC)C(=O)c1ccc(cc1)C(=C2C3CC(C2)N3CCc4ccccc4)c5ccccc5
  • InChI=1S/C33H38N2O/c1-3-34(4-2)33(36)28-17-15-27(16-18-28)32(26-13-9-6-10-14-26)29-23-30-19-20-31(24-29)35(30)22-21-25-11-7-5-8-12-25/h5-18,30-31H,3-4,19-24H2,1-2H3/b32-29-/t30-,31+/m1/s1
  • Key:ZJOPBPNTQRUJNM-BPVGFELESA-N
  (verify)

RWJ-394674 is a drug that is used in scientific research. It is a potent, orally active analgesic drug that produces little respiratory depression. RWJ-394674 itself is a potent and selective agonist for δ-opioid receptors, with a Ki of 0.24 nM at δ and 72 nM at μ. However once inside the body, RWJ-394674 is dealkylated to its monodesethyl metabolite RWJ-413216, which is a potent agonist at the μ-opioid receptor and has less affinity for δ (Ki of 0.26 nM at μ, 46.7 nM at δ). The effect of RWJ-394674 when administered in vivo thus produces potent agonist effects at both μ and δ receptors through the combined actions of the parent drug and its active metabolite, with the δ-agonist effects counteracting the respiratory depression from the μ-opioid effects, and the only prominent side-effect being sedation.[1]

References

  1. ^ Codd EE, Carson JR, Colburn RW, Dax SL, Desai-Krieger D, Martinez RP, et al. (September 2006). "The novel, orally active, delta opioid RWJ-394674 is biotransformed to the potent mu opioid RWJ-413216". The Journal of Pharmacology and Experimental Therapeutics. 318 (3): 1273–9. doi:10.1124/jpet.106.104208. PMID 16766719. S2CID 13165519.


Stub icon

This analgesic-related article is a stub. You can help Wikipedia by expanding it.