Fedotozine

Clinical data
Routes of administration	Oral
ATC code	None
Legal status
Legal status	In general: non-regulated
Identifiers
IUPAC name (2R)-N,N-dimethyl-2-phenyl-1--2-butanamine
CAS Number	123618-00-8 133267-27-3 (tartrate)
PubChem CID	6918160
ChemSpider	5293373
UNII	F45VW2087W
ChEMBL	ChEMBL2106275
CompTox Dashboard (EPA)	DTXSID901318556
Chemical and physical data
Formula	C22H31NO4
Molar mass	373.493 g·mol−1
3D model (JSmol)	Interactive image
SMILES O(c1cc(cc(OC)c1OC)COC(c2ccccc2)(N(C)C)CC)C
InChI InChI=1S/C22H31NO4/c1-7-22(23(2)3,18-11-9-8-10-12-18)16-27-15-17-13-19(24-4)21(26-6)20(14-17)25-5/h8-14H,7,15-16H2,1-6H3/t22-/m0/s1 Key:MVKIWCDXKCUDEH-QFIPXVFZSA-N

Fedotozine (INN; JO 1196 for the (-) tartrate salt) is an opioid drug which acts as a peripherally specific selective κ1-opioid receptor agonist with preference for the κ1A subtype. It was under investigation for the treatment of gastrointestinal conditions like irritable bowel syndrome and functional dyspepsia and made it to phase III clinical trials, but ultimately development was discontinued and it was never marketed.

See also

• Asimadoline
• Trimebutine

References

1. ^ a b Delvaux M (January 2001). "Pharmacology and clinical experience with fedotozine". Expert Opinion on Investigational Drugs. 10 (1): 97–110. doi:10.1517/13543784.10.1.97. PMID 11116283. S2CID 41361900.
2. ^ Barber A, Gottschlich R (October 1997). "Novel developments with selective, non-peptidic kappa-opioid receptor agonists". Expert Opinion on Investigational Drugs. 6 (10): 1351–68. doi:10.1517/13543784.6.10.1351. PMID 15989506.
3. ^ Lembo A (2006). "Peripheral opioids for functional GI disease: a reappraisal". Digestive Diseases. 24 (1–2): 91–8. doi:10.1159/000090312. PMID 16699267. S2CID 29627937.