Gossypetin

This article will address the topic of Gossypetin, which has gained relevance in recent years due to its impact on different aspects of society. From Gossypetin has marked a before and after in the way we relate, to its influence in the economic and political sphere, this topic has sparked great interest and debate among experts and citizens alike. Along these lines, the origin, evolution and repercussions of Gossypetin will be analyzed, offering a detailed look at its present and future implications and challenges.

Not to be confused with Gossypol.
Gossypetin
Skeletal formula of gossypetin
Ball-and-stick model of the gossypetin molecule
Names
IUPAC name
3,3′,4′,5,7,8-Hexahydroxyflavone
Systematic IUPAC name
2-(3,4-Dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-1-benzopyran-4-one
Other names
Articulatidin
Equisporol
3,5,7,8,3',4'-Hexahydroxyflavone
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H ☒N
    Key: YRRAGUMVDQQZIY-UHFFFAOYSA-N ☒N
  • InChI=1/C15H10O8/c16-6-2-1-5(3-7(6)17)14-13(22)12(21)10-8(18)4-9(19)11(20)15(10)23-14/h1-4,16-20,22H
    Key: YRRAGUMVDQQZIY-UHFFFAOYAI
  • C1=CC(=C(C=C1C2=C(C(=O)C3=C(O2)C(=C(C=C3O)O)O)O)O)O
Properties
C15H10O8
Molar mass 318.23 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
☒N verify (what is checkY☒N ?)

Gossypetin, also known as 3,5,7,8,3',4'-hexahydroxyflavone, is a flavonol, a type of flavonoid. It has been isolated from the flowers and the calyx of Hibiscus sabdariffa (roselle) and exhibits a strong antibacterial activity.[1][2] The compound has also been found to act as an antagonist of TrkB.[3] Gossypetin has radioprotective activity.[citation needed]

The enzyme 8-hydroxyquercetin 8-O-methyltransferase uses S-adenosyl methionine and gossypetin to produce S-adenosylhomocysteine and 3,5,7,3',4'-pentahydroxy-8-methoxyflavone.[citation needed]

In 2022, a study in an animal model using intragastric administration suggested that the flavonoid gossypetin facilitated the clearance of beta-amyloid in the brain and is a promising target for the study of treatments for Alzheimer's Disease by enhancing microglial phagocytic activity against Aβ.[4]

See also

References

  1. ^ "Antibacterial activity of gossypetin isolated from hibiscus sabdariffa". Archived from the original on 2007-12-05. Retrieved 2008-04-23.
  2. ^ Amitava Khan, Krishnendu Manna, Chinchubose, Mahuya Sinha, Dipesh Kr Das, Swaraj Bandhu Kesh, Anindita Chakrabarty, Asoke Banerji & Sanjit Dey: Gossypetin, a naturally occurring hexahydroxy flavones ameliorates gamma radiation mediated DNA damage International Journal of Radiation Biology (2013):89(11): 965-975.
  3. ^ Obianyo, Obiamaka; Ye, Keqiang (2013). "Novel small molecule activators of the Trk family of receptor tyrosine kinases". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1834 (10): 2213–2218. doi:10.1016/j.bbapap.2012.08.021. ISSN 1570-9639. PMC 3602283. PMID 22982231.
  4. ^ Jo, Kyung Won; Lee, Dohyun; Cha, Dong Gon; Oh, Eunji; Choi, Yoon Ha; Kim, Somi; Park, Eun Seo; Kim, Jong Kyoung; Kim, Kyong-Tai (2022). "Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Aβ". Alzheimer's Research & Therapy. 14 (1): 158. doi:10.1186/s13195-022-01096-3. PMC 9585741. PMID 36271414.


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