Vilaprisan

In today's world, Vilaprisan has gained impressive relevance. Whether in the field of technology, health, politics or entertainment, Vilaprisan has managed to capture the attention of millions of people around the world. Its impact has been felt significantly, generating both enthusiasm and controversy. In this article, we will thoroughly explore the phenomenon of Vilaprisan, from its origins to its influence on today's society. Through a detailed analysis, we will discover how Vilaprisan has transformed the way we think, interact, and perceive the world around us.

Vilaprisan
Clinical data
Other namesBAY-1002670; 17β-Hydroxy-11β--17α-(1,1,2,2,2-pentafluoroethyl)estra-4,9-dien-3-one
Routes of
administration		By mouth
Drug classSelective progesterone receptor modulator
Identifiers
  • (8S,11R,13S,14S,17S)-17-Hydroxy-13-methyl-11-(4-methylsulfonylphenyl)-17-(1,1,2,2,2-pentafluoroethyl)-1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaphenanthren-3-one
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC27H29F5O4S
Molar mass544.58 g·mol−1
3D model (JSmol)
  • C12C(C3=C4CCC(=O)C=C4CC31CC2(C(C(F)(F)F)(F)F)O)C5=CC=C(C=C5)S(=O)(=O)C
  • InChI=1S/C27H29F5O4S/c1-24-14-21(15-3-7-18(8-4-15)37(2,35)36)23-19-10-6-17(33)13-16(19)5-9-20(23)22(24)11-12-25(24,34)26(28,29)27(30,31)32/h3-4,7-8,13,20-22,34H,5-6,9-12,14H2,1-2H3/t20-,21+,22-,24-,25-/m0/s1
  • Key:JUFWQQVHQFDUOD-ANRPBIDPSA-N

Vilaprisan (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name) (developmental code name BAY-1002670) is a synthetic and steroidal selective progesterone receptor modulator (SPRM) which is under development by Bayer HealthCare Pharmaceuticals for the treatment of endometriosis and uterine fibroids.[1][2][3] It is a potent and highly selective partial agonist of the progesterone receptor (PR).[4][2][3] As of 2017, the drug is in phase II clinical trials for the aforementioned indications.[1]

See also

References

  1. ^ a b "Vilaprisan - Bayer HealthCare Pharmaceuticals - AdisInsight".
  2. ^ a b Whitaker LH, Williams AR, Critchley HO (2014). "Selective progesterone receptor modulators". Curr. Opin. Obstet. Gynecol. 26 (4): 237–42. doi:10.1097/GCO.0000000000000082. PMID 24950125. S2CID 37474964.
  3. ^ a b Pluchino N, Freschi L, Wenger JM, Streuli I (2016). "Innovations in classical hormonal targets for endometriosis". Expert Rev Clin Pharmacol. 9 (2): 317–27. doi:10.1586/17512433.2016.1129895. PMID 26645363. S2CID 8624056.
  4. ^ Schütt B, Kaiser A, Schultze-Mosgau MH, Seitz C, Bell D, Koch M, Rohde B (2016). "Pharmacodynamics and safety of the novel selective progesterone receptor modulator vilaprisan: a double-blind, randomized, placebo-controlled phase 1 trial in healthy women". Hum. Reprod. 31 (8): 1703–12. doi:10.1093/humrep/dew140. PMID 27288475.


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