Megestrol

In today's world, Megestrol is a topic that has become increasingly relevant. Over the years, Megestrol has generated great interest in society, sparking debates, research and different positions around this issue. It is evident that Megestrol has impacted our lives in some way, whether on a social, cultural, economic or personal level. For this reason, it is important to thoroughly analyze and understand the implications and consequences that Megestrol brings with it, as well as to be aware of the trends and advances that are developing in relation to this topic. In this article we will explore various perspectives and approaches on Megestrol, with the aim of providing a complete and enriching overview that allows the reader to delve deeper into this topic.

This article is about a progestin compound. For the pharmaceutical drug, see megestrol acetate.

Megestrol
Clinical data
ATC code
Identifiers
  • 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.020.571 Edit this at Wikidata
Chemical and physical data
FormulaC22H30O3
Molar mass342.479 g·mol−1
3D model (JSmol)
  • O=C4\C=C3\C(=C/1(CC2((O)(C(=O)C)CC12)C)3(C)CC4)C
  • InChI=1S/C22H30O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h11-12,16-18,25H,5-10H2,1-4H3/t16-,17+,18+,20-,21+,22+/m1/s1 checkY
  • Key:VXIMPSPISRVBPZ-NWUMPJBXSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Megestrol (INNTooltip International Nonproprietary Name, BANTooltip British Approved Name) is a progestin of the 17α-hydroxyprogesterone group which was, until recently, never marketed or used clinically.[1][2] It is now used for treatments of disease-related weight loss, endometrial cancer, and breast cancer.[3] Its acylated derivative megestrol acetate is also a progestogen, which, in contrast to megestrol itself, has been extensively used as a pharmaceutical drug.[1][2]

Medical Use

As of June 2023, megestrol is being used to treat significant weight loss in HIV/AIDS patients, and as a palliative treatment of endometrial and breast cancers. It can be administered in both tablet and oral suspension forms, with dosages ranging from 100 mg/day to 1600 mg/day depending on the condition being treated.[3]

Synthesis

Megestrol synthesis:[4] U.S. patent 2,891,079

See also

References

  1. ^ a b Macdonald F (1997). Dictionary of Pharmacological Agents. CRC Press. p. 1267. ISBN 978-0-412-46630-4. Retrieved 12 May 2012.
  2. ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 641. ISBN 978-3-88763-075-1. Retrieved 28 May 2012.
  3. ^ a b Manikkuttiyil C, Nguyen H (2024). "Megestrol". StatPearls. Treasure Island (FL): StatPearls Publishing. PMID 32644631. Retrieved 2024-04-25.
  4. ^ Ringold HJ, Ruelas JP, Batres E, Djerassi C (1959). "Steroids. CXVIII.16-Methyl Derivatives of 17α-Hydroxyprogesterone and of Reichstein's Substance "S"". Journal of the American Chemical Society. 81 (14): 3712–3716. Bibcode:1959JAChS..81.3712R. doi:10.1021/ja01523a055.
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