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Preferred IUPAC name N,N,N-Trimethyl-3-(trifluoroacetyl)anilinium | |
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Properties | |
Chemical formula | C11H13F3NO |
Molar mass | 232.226 g·mol−1 |
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Lethal dose or concentration (LD, LC): | |
LD50 (median dose) | 1.6 mg/kg (intraperitoneal, mice) (as iodide salt) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references |
TMTFA is an extremely potent acetylcholinesterase inhibitor. As a transition state analog of acetylcholinesterase, TMTFA is able to inhibit acetylcholinesterase at extremely low concentrations (within the femtomolar range), making it one of the most potent acetylcholinesterase inhibitors known.
TMTFA has a reactive ketone group that can covalently bind to the serine residue in the active site of acetylcholinesterase. This is due to the electron-withdrawing trifluoromethyl group on the carbonyl group.
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