Ro 3-0422

In this article, Ro 3-0422 will be addressed from a broad and detailed perspective, in order to provide the reader with a complete vision of this topic/person/date. Various aspects related to Ro 3-0422 will be explored, with the purpose of providing relevant and updated information about it. Likewise, its implications, effects and consequences will be analyzed, with the aim of offering a comprehensive and enriching vision of Ro 3-0422. Throughout this writing, different approaches and points of view will be appealed to, with the purpose of building as complete and diverse a panorama as possible about Ro 3-0422.

Ro 3-0422
Names
Preferred IUPAC name
3--1-methylquinolin-1-ium methyl sulfate
Other names
3-(Diethoxyphosphinyloxy)-1-methylquinolinium methylsulfate
Identifiers
3D model (JSmol)
ChemSpider
  • CCOP(=O)(OCC)Oc1cc2ccccc2(c1)C.COS(=O)(=O)
Properties
C15H22NO8PS
Molar mass 407.37 g·mol−1
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
 Extremely toxic
Lethal dose or concentration (LD, LC):
20 μg/kg (mice, intravenous)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

Ro 3-0422 is an extremely potent organophosphate acetylcholinesterase inhibitor. It is extremely toxic. The intravenous LD50 is 20 μg/kg in mice.[1] It is over 300 times more potent than neostigmine.[2]

See also

References

  1. ^ HOBBIGER, F (June 1954). "The inhibition of cholinesterases by 3-(diethoxyphosphinyloxy)-N-methylquinolinium methylsulphate and its tertiary base". British Journal of Pharmacology and Chemotherapy. 9 (2): 159–65. doi:10.1111/j.1476-5381.1954.tb00835.x. PMC 1509437. PMID 13172424.
  2. ^ Andrews, K. J. M.; Atherton, F. R.; Bergel, F.; Morrison, A. L. (1954). "Hydroxypyridine and hydroxyquinoline phosphates as anti-cholinesterases". Journal of the Chemical Society (Resumed): 1638. doi:10.1039/jr9540001638.
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