L-163,491

In today's world, L-163,491 is a topic that has gained unprecedented relevance. Whether in the social, political, economic or technological sphere, L-163,491 has become a point of interest for individuals and organizations around the world. Its impact ranges from people's daily lives to strategic decisions at a global level. In this article, we will thoroughly explore the importance of L-163,491 and analyze how it is shaping the present and future of society. Furthermore, we will examine its implications in different contexts and how it is being addressed by different actors.

L-163,491
Legal status
Legal status
  • US: Investigational drug
Identifiers
  • Butyl (4'-((2-ethyl-5,7-dimethyl-3H-imidazopyridin-3-yl)methyl)-5-(3-methoxybenzyl)--2-yl)sulfonylcarbamate
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC36H40N4O5S
Molar mass640.80 g·mol−1
3D model (JSmol)
  • CCCCOC(=O)NS(=O)(=O)C1=C(C=C(C=C1)CC2=CC(=CC=C2)OC)C3=CC=C(C=C3)CN4C(=NC5=C4N=C(C=C5C)C)CC
  • InChI=1S/C36H40N4O5S/c1-6-8-18-45-36(41)39-46(42,43)32-17-14-28(20-27-10-9-11-30(21-27)44-5)22-31(32)29-15-12-26(13-16-29)23-40-33(7-2)38-34-24(3)19-25(4)37-35(34)40/h9-17,19,21-22H,6-8,18,20,23H2,1-5H3,(H,39,41)
  • Key:SRCIRAKBWHTYIX-UHFFFAOYSA-N

L-163,491 is an experimental drug which acts as a partial agonist of angiotensin II receptor type 1, and with lower affinity as an agonist of angiotensin II receptor type 2, mimicking the action of angiotensin II.[1] Its practical applications to date have been limited to scientific research into the function of the angiotensin receptor system,[2] but it has been suggested as a potential therapeutic agent for the treatment of inflammation of the lungs associated with certain viral diseases such as COVID-19.[3][4]

References

  1. ^ De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ (September 2000). "L-163,491 is a partial angiotensin AT(1) receptor agonist in the hindquarters vascular bed of the cat". European Journal of Pharmacology. 404 (1–2): 213–9. doi:10.1016/s0014-2999(00)00612-9. PMID 10980281.
  2. ^ Alterman M (March 2010). "Development of selective non-peptide angiotensin II type 2 receptor agonists". Journal of the Renin-Angiotensin-Aldosterone System. 11 (1): 57–66. doi:10.1177/1470320309347790. PMID 19880657.
  3. ^ Liu C, Zhou Q, Li Y, Garner LV, Watkins SP, Carter LJ, et al. (2020). "Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases". ACS Central Science. 6 (3): 315–331. doi:10.1021/acscentsci.0c00272. PMC 7094090. PMID 32226821.
  4. ^ Wu Y (February 2020). "Compensation of ACE2 Function for Possible Clinical Management of 2019-nCoV-Induced Acute Lung Injury". Virologica Sinica. 35 (3): 256–258. doi:10.1007/s12250-020-00205-6. PMC 7091449. PMID 32034638.


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