Kir2.6
In this article, we are going to explore the fascinating life of Kir2.6, an individual who has left his mark throughout history. From his humble beginnings to his most outstanding achievements, Kir2.6 has been an influential figure in his field. Through a detailed analysis of his career, we will discover the reasons behind his success and the impact he has had on the world around him. With an in-depth look at his experiences, achievements, and challenges, we hope to shed light on the importance of Kir2.6 and his lasting legacy.
| potassium inwardly-rectifying channel, subfamily J, member 18 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | KCNJ18 | ||||||
| NCBI gene | 100134444 | ||||||
| HGNC | 39080 | ||||||
| OMIM | 613236 | ||||||
| RefSeq | NM_001194958 | ||||||
| UniProt | B7U540 | ||||||
| Other data | |||||||
| Locus | Chr. 17 p11.2 | ||||||
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The Kir2.6 also known as inward rectifier potassium channel 18 is a protein that in humans is encoded by the KCNJ18 gene.[1] Kir2.6 is an inward-rectifier potassium ion channel.
Function
Inwardly rectifying potassium channels, such as Kir2.6, maintain resting membrane potential in excitable cells and aid in repolarization of cells following depolarization. Kir2.6 is primarily expressed in skeletal muscle and is transcriptionally regulated by thyroid hormone.[1]
Clinical significance
Mutations in this gene have been linked to thyrotoxic periodic paralysis.[1]
References
- ^ a b c Ryan DP, da Silva MR, Soong TW, et al. (January 2010). "Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis". Cell. 140 (1): 88–98. doi:10.1016/j.cell.2009.12.024. PMC 2885139. PMID 20074522.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.