KCNA10

In this article, we are going to address the topic of KCNA10 with the aim of exploring its various facets and delving into its meaning and relevance today. KCNA10 is a topic that has aroused the interest of experts and the general public, due to its impact on different aspects of daily life. Throughout history, KCNA10 has played a crucial role in society, and its influence remains significant today. Through this article, we will seek to shed light on the different aspects of KCNA10, analyzing its evolution over time and its relevance in the contemporary world.

Protein-coding gene in the species Homo sapiens

KCNA10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AFL
Identifiers
Aliases	KCNA10, Kcn1, Kv1.8, potassium voltage-gated channel subfamily A member 10
External IDs	OMIM: 602420; MGI: 3037820; HomoloGene: 4054; GeneCards: KCNA10; OMA:KCNA10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p13.3 Start 110,517,217 bp[1] End 110,519,175 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F2.3|3 46.64 cM Start 107,090,372 bp[2] End 107,103,037 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stomach testicle left testis right testis Top expressed in embryo quadriceps femoris muscle skeletal muscle tissue Hypothalamus muscle of thigh spleen More reference expression data BioGPS n/a
Gene ontology Molecular function intracellular cyclic nucleotide activated cation channel activity voltage-gated ion channel activity ion channel activity potassium channel activity voltage-gated potassium channel activity delayed rectifier potassium channel activity outward rectifier potassium channel activity Cellular component plasma membrane membrane voltage-gated potassium channel complex integral component of membrane Biological process ion transport transmembrane transport potassium ion transport protein homooligomerization regulation of ion transmembrane transport potassium ion transmembrane transport potassium ion export across plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3744 242151 Ensembl ENSG00000143105 ENSMUSG00000042861 UniProt Q16322 B2RQA1 RefSeq (mRNA) NM_005549 NM_001081140 RefSeq (protein) NP_005540 NP_001074609 Location (UCSC) Chr 1: 110.52 – 110.52 Mb Chr 3: 107.09 – 107.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily A member 10 also known as K_v1.8 is a protein that in humans is encoded by the KCNA10 gene.^[5] The protein encoded by this gene is a voltage-gated potassium channel subunit.

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000143105 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000042861 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

• Landes GM, Curran ME, Keating MT (1995). "Molecular characterization and refined genomic localization of three human potassium ion channel genes". Cytogenet. Cell Genet. 70 (3–4): 280–4. doi:10.1159/000134052. PMID 7789190.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tian S, Liu W, Wu Y, et al. (2002). "Regulation of the voltage-gated K+ channel KCNA10 by KCNA4B, a novel beta-subunit". Am. J. Physiol. Renal Physiol. 283 (1): F142–9. doi:10.1152/ajprenal.00258.2001. PMID 12060596. S2CID 87148775.
• Orias M, Bray-Ward P, Curran ME, et al. (1997). "Genomic localization of the human gene for KCNA10, a cGMP-activated K channel". Genomics. 42 (1): 33–7. doi:10.1006/geno.1997.4712. PMID 9177773.
• Lang R, Lee G, Liu W, et al. (2000). "KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels". Am. J. Physiol. Renal Physiol. 278 (6): F1013–21. doi:10.1152/ajprenal.2000.278.6.F1013. PMID 10836990. S2CID 15360695.
• Yao X, Tian S, Chan HY, et al. (2002). "Expression of KCNA10, a voltage-gated K channel, in glomerular endothelium and at the apical membrane of the renal proximal tubule". J. Am. Soc. Nephrol. 13 (12): 2831–9. doi:10.1097/01.ASN.0000036866.37886.C5. PMID 12444201.

External links

• Kv1.8+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNA10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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