KCNV2

In this article we are going to talk about KCNV2, a topic that has generated great interest in recent times. KCNV2 has been the subject of numerous debates, research and reflections by experts and the general public. Its relevance has transcended borders and has impacted different areas of society, from politics to popular culture. This is why it is essential to dedicate time and attention to deeply understanding what KCNV2 is, what its implications are and how its presence has shaped the contemporary world. Throughout this article we will explore various perspectives on KCNV2, with the aim of shedding light on its importance and the challenges it poses.

Protein-coding gene in the species Homo sapiens

KCNV2
Identifiers
Aliases	KCNV2, KV11.1, Kv8.2, RCD3B, potassium voltage-gated channel modifier subfamily V member 2
External IDs	OMIM: 607604; MGI: 2670981; HomoloGene: 26423; GeneCards: KCNV2; OMA:KCNV2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.2 Start 2,717,510 bp[1] End 2,730,037 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 27,299,988 bp[2] End 27,314,579 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm testicle gonad retinal pigment epithelium right testis left testis sural nerve pancreatic ductal cell right hemisphere of cerebellum ganglionic eminence Top expressed in neural layer of retina outer nuclear layer embryo blastocyst gastrula lumbar subsegment of spinal cord inner nuclear layer zygote lumbar spinal ganglion sternocleidomastoid muscle More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity potassium channel activity voltage-gated ion channel activity voltage-gated potassium channel activity Cellular component integral component of membrane voltage-gated potassium channel complex plasma membrane membrane Biological process potassium ion transport regulation of ion transmembrane transport protein homooligomerization ion transport transmembrane transport potassium ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 169522 240595 Ensembl ENSG00000168263 ENSMUSG00000047298 UniProt Q8TDN2 Q8CFS6 RefSeq (mRNA) NM_133497 NM_183179 RefSeq (protein) NP_598004 NP_899002 Location (UCSC) Chr 9: 2.72 – 2.73 Mb Chr 19: 27.3 – 27.31 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Potassium voltage-gated channel subfamily V member 2 is a protein that in humans is encoded by the KCNV2 gene.^[5][6] The protein encoded by this gene is a voltage-gated potassium channel subunit.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000168263 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000047298 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b} Ottschytsch N, Raes A, Van Hoorick D, Snyders DJ (Jun 2002). "Obligatory heterotetramerization of three previously uncharacterized Kv channel alpha-subunits identified in the human genome". Proc Natl Acad Sci U S A. 99 (12): 7986–91. Bibcode:2002PNAS...99.7986O. doi:10.1073/pnas.122617999. PMC 123007. PMID 12060745.
6. ^ ^{a b} Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104. S2CID 219195192.

Further reading

• Wu H, Cowing JA, Michaelides M, et al. (2006). "Mutations in the gene KCNV2 encoding a voltage-gated potassium channel subunit cause "cone dystrophy with supernormal rod electroretinogram" in humans". Am. J. Hum. Genet. 79 (3): 574–9. doi:10.1086/507568. PMC 1559534. PMID 16909397.
• Ben Salah S; Kamei S; Sénéćhal A; et al. (2008). "Novel KCNV2 mutations in cone dystrophy with supernormal rod electroretinogram". Am. J. Ophthalmol. 145 (6): 1099–106. doi:10.1016/j.ajo.2008.02.004. PMID 18400204. S2CID 8716306.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Balijepalli RC, Delisle BP, Balijepalli SY, et al. (2007). "Kv11.1 (ERG1) K+ channels localize in cholesterol and sphingolipid enriched membranes and are modulated by membrane cholesterol". Channels (Austin). 1 (4): 263–72. doi:10.4161/chan.4946. PMID 18708743.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Thiagalingam S, McGee TL, Weleber RG, et al. (2007). "Novel mutations in the KCNV2 gene in patients with cone dystrophy and a supernormal rod electroretinogram". Ophthalmic Genet. 28 (3): 135–42. doi:10.1080/13816810701503681. PMID 17896311. S2CID 6288000.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Wissinger B, Dangel S, Jägle H, et al. (2008). "Cone dystrophy with supernormal rod response is strictly associated with mutations in KCNV2". Invest. Ophthalmol. Vis. Sci. 49 (2): 751–7. doi:10.1167/iovs.07-0471. PMID 18235024.

External links

• Kv8.2+Potassium+Channel at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• KCNV2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

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