HPTE

The topic of HPTE has been the subject of interest and debate for a long time. Whether academically, professionally, or personally, HPTE has captured the attention of people of all ages and backgrounds. As society advances and new technologies are developed, it has become even more relevant to understand and analyze HPTE from different perspectives. In this article, we will examine various facets of HPTE, exploring its impact on everyday life, its importance in history, and its relevance in the current context. By delving deeper into this topic, we hope to shed light on its meaning and influence on today's society.

HPTE
Names
Preferred IUPAC name
4,4′-(2,2,2-Trichloroethane-1,1-diyl)diphenol
Other names
p,p'-Hydroxy-DDT
Hydroxychlor
2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane
1,1,1-Trichloro-2,2-bis(4-hydroxyphenyl)ethane
Identifiers
3D model (JSmol)
2054671
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.152.496 Edit this at Wikidata
EC Number
  • 623-854-1
KEGG
UNII
  • InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
    Key: IUGDILGOLSSKNE-UHFFFAOYSA-N
  • InChI=1S/C14H11Cl3O2/c15-14(16,17)13(9-1-5-11(18)6-2-9)10-3-7-12(19)8-4-10/h1-8,13,18-19H
    Key: IUGDILGOLSSKNE-UHFFFAOYSA-N
  • C1=CC(=CC=C1C(C2=CC=C(C=C2)O)C(Cl)(Cl)Cl)O
Properties
C14H11Cl3O2
Molar mass 317.59 g·mol−1
Hazards
GHS labelling:
GHS07: Exclamation mark
Warning
H315, H319, H335
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

HPTE, also known as hydroxychlor, p,p'-hydroxy-DDT, or 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane, is a metabolite of methoxychlor, a synthetic insecticide related to DDT.[1] Like bisphenol A with similar chemical structure, HPTE is an endocrine disruptor which has estrogenic activity,[2] and also inhibits Cholesterol side-chain cleavage enzyme (P450scc, CYP11A1)[3] and 3α-hydroxysteroid dehydrogenase (3α-HSD).[4]

References

  1. ^ Leung-Gurung, Lucie; Escalante Cobb, Priscilla; Mourad, Faraj; Zambrano, Cristina; Muscato, Zachary; Sanchez, Victoria; Godde, Kanya; Broussard, Christine (4 July 2018). "Methoxychlor metabolite HPTE alters viability and differentiation of embryonic thymocytes from C57BL/6 mice". Journal of Immunotoxicology. 15 (1): 104–118. doi:10.1080/1547691X.2018.1474978. PMC 6120686. PMID 29973080.
  2. ^ Hewitt, Sylvia C.; Korach, Kenneth S. (January 2011). "Estrogenic Activity of Bisphenol A and 2,2-bis(p-Hydroxyphenyl)-1,1,1-trichloroethane (HPTE) Demonstrated in Mouse Uterine Gene Profiles". Environmental Health Perspectives. 119 (1): 63–70. Bibcode:2011EnvHP.119...63H. doi:10.1289/EHP.1002347. PMC 3018502. PMID 20826375.
  3. ^ Akgul, Yucel; Derk, Raymond C.; Meighan, Terence; Rao, K. Murali Krishna; Murono, Eisuke P. (July 2011). "The methoxychlor metabolite, HPTE, inhibits rat luteal cell progesterone production". Reproductive Toxicology. 32 (1): 77–84. Bibcode:2011RepTx..32...77A. doi:10.1016/J.REPROTOX.2011.05.013. PMID 21664964.
  4. ^ Mao, Baiping; Wu, Chengyun; Zheng, Wenwen; Shen, Qiuxia; Wang, Yiyan; Wang, Qiufan; Lin, Han; Li, Xiaoheng; Sun, Jianliang; Ge, Ren-Shan (September 2018). "Methoxychlor and its metabolite HPTE inhibit rat neurosteroidogenic 3α-hydroxysteroid dehydrogenase and retinol dehydrogenase 2". Neuroscience Letters. 684: 169–174. doi:10.1016/j.neulet.2018.08.008. PMID 30107201. S2CID 52004606.


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