UQCRC1

In today's world, UQCRC1 has become a topic of great relevance and interest to a wide range of people. The importance of UQCRC1 in our society has grown in recent years, and its impact can be felt in many aspects of daily life. Both in the personal and professional spheres, UQCRC1 has proven to be a determining factor in decision-making and in the configuration of our beliefs and values. In this article we will closely explore the role UQCRC1 plays in our society and how it has evolved over time. In addition, we will analyze its influence in different sectors and its relevance in the contemporary world.

Protein-coding gene in the species Homo sapiens

UQCRC1
Identifiers
Aliases	UQCRC1, D3S3191, QCR1, UQCR1, ubiquinol-cytochrome c reductase core protein I, ubiquinol-cytochrome c reductase core protein 1, PKNPY
External IDs	OMIM: 191328; MGI: 107876; HomoloGene: 2525; GeneCards: UQCRC1; OMA:UQCRC1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,599,002 bp[1] End 48,610,976 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F2|9 59.63 cM Start 108,765,701 bp[2] End 108,778,691 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right ventricle triceps brachii muscle myocardium of left ventricle gastrocnemius muscle muscle of thigh mucosa of transverse colon right auricle of heart vastus lateralis muscle Top expressed in proximal tubule heart right kidney muscle tissue muscle of thigh skeletal muscle tissue quadriceps femoris muscle human kidney neural layer of retina duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquinol-cytochrome-c reductase activity protein-containing complex binding zinc ion binding metal ion binding catalytic activity metalloendopeptidase activity ubiquitin protein ligase binding Cellular component mitochondrial respiratory chain complex III membrane myelin sheath mitochondrion mitochondrial respirasome mitochondrial inner membrane respirasome cytosol Biological process protein processing response to activity aerobic respiration oxidative phosphorylation response to alkaloid mitochondrial electron transport, ubiquinol to cytochrome c proton transmembrane transport proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7384 22273 Ensembl ENSG00000010256 ENSMUSG00000025651 UniProt P31930 Q9CZ13 RefSeq (mRNA) NM_003365 NM_025407 RefSeq (protein) NP_003356 NP_079683 Location (UCSC) Chr 3: 48.6 – 48.61 Mb Chr 9: 108.77 – 108.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytochrome b-c1 complex subunit 1, mitochondrial is a protein that in humans is encoded by the UQCRC1 gene.^[5][6]

Its gene product is a subunit of the respiratory chain protein Ubiquinol Cytochrome c Reductase (UQCR, Complex III or Cytochrome bc1 complex), which consists of the products of one mitochondrially encoded gene, MTCYTB (mitochondrial cytochrome b) and ten nuclear genes: UQCRC1, UQCRC2, Cytochrome c1, UQCRFS1 (Rieske protein), UQCRB, "11kDa protein", UQCRH (cyt c1 Hinge protein), Rieske Protein presequence, "cyt. c1 associated protein", and Rieske-associated protein.

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000010256 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000025651 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hoffman GG, Lee S, Christiano AM, Chung-Honet LC, Cheng W, Katchman S, Uitto J, Greenspan DS (Nov 1993). "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase". J Biol Chem. 268 (28): 21113–9. doi:10.1016/S0021-9258(19)36900-5. PMID 8407948.
6. ^ "Entrez Gene: UQCRC1 ubiquinol-cytochrome c reductase core protein I".

Further reading

• Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1991). "Existence of common homologous elements in the transcriptional regulatory regions of human nuclear genes and mitochondrial gene for the oxidative phosphorylation system". J. Biol. Chem. 266 (4): 2333–8. doi:10.1016/S0021-9258(18)52248-1. PMID 1846623.
• Broger C, Nałecz MJ, Azzi A (1980). "Interaction of cytochrome c with cytochrome bc1 complex of the mitochondrial respiratory chain". Biochim. Biophys. Acta. 592 (3): 519–27. doi:10.1016/0005-2728(80)90096-1. PMID 6251869.
• Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (2): 410. PMID 7951059.
• Islam MM, Tanaka M, Suzuki H, et al. (1995). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 33 (4): 815. PMID 7981668.
• Islam MM, Tanaka M, Suzuki H, et al. (1994). "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase". Biochem. Mol. Biol. Int. 32 (5): 797–805. PMID 8069229.
• Hughes GJ, Frutiger S, Paquet N, et al. (1994). "Human liver protein map: update 1993". Electrophoresis. 14 (11): 1216–22. doi:10.1002/elps.11501401181. PMID 8313870. S2CID 33424554.
• Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
• Valnot I, Kassis J, Chretien D, et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733. S2CID 30584267.
• Hu WH, Hausmann ON, Yan MS, et al. (2002). "Identification and characterization of a novel Nogo-interacting mitochondrial protein (NIMP)". J. Neurochem. 81 (1): 36–45. doi:10.1046/j.1471-4159.2002.00788.x. PMID 12067236. S2CID 38794348.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aboulaich N, Vainonen JP, Strålfors P, Vener AV (2005). "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes". Biochem. J. 383 (Pt 2): 237–48. doi:10.1042/BJ20040647. PMC 1134064. PMID 15242332.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wen JJ, Garg N (2005). "Oxidative modification of mitochondrial respiratory complexes in response to the stress of Trypanosoma cruzi infection". Free Radic. Biol. Med. 37 (12): 2072–81. doi:10.1016/j.freeradbiomed.2004.09.011. PMID 15544925.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Kulawiec M, Arnouk H, Desouki MM, et al. (2007). "Proteomic analysis of mitochondria-to-nucleus retrograde response in human cancer". Cancer Biol. Ther. 5 (8): 967–75. doi:10.4161/cbt.5.8.2880. PMID 16775426. S2CID 84608368.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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