Retatrutide

In this article, we will explore in depth the relevance of Retatrutide in different contexts and circumstances. From its impact on society to its influence on popular culture, Retatrutide has left a significant mark on various aspects of everyday life. Through detailed analysis, we will examine the many facets of Retatrutide and its importance in today's world. Furthermore, we will explore how Retatrutide has evolved over time and what future projections can be anticipated in relation to this phenomenon. From its origin to its legacy, this article will provide a comprehensive view of Retatrutide and its significance in the contemporary landscape.

Retatrutide
Clinical data
Other namesLY-3437943
Identifiers
  • L-tyrosyl-2-methylalanyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-alpha -aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-2-methyl-L-leucyl-Lleucyl-L-alpha -aspartyl-L-lysyl-N6-(N-(19-carboxy-1-oxononadecyl)-L-gamma-glutamyl-2-(2-(2-aminoethoxy)ethoxy)acetyl)-L-lysyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-alanyl-Lphenylalanyl-L-isoleucyl-L-alpha -glutamyl-L-tyrosyl-L-leucyl-L-leucyl-L-alpha -glutamylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide
CAS Number
UNII
ChEMBL

Retatrutide (LY-3437943) is an experimental drug for obesity developed by American pharmaceutical company Eli Lilly and Company. It is a triple glucagon hormone receptor agonist (GLP-1, GIP, and GCGR receptors).[1] It has been shown to achieve a more than 17.5% mean weight reduction in adults without diabetes but with obesity or preobesity (overweight) during a phase 2 trial.[2][3][4]

Chemistry

The drug is a peptide with amino acid sequence[5] 

YA¹QGTFTSDYSIL²LDKK⁴AQA¹AFIEYLLEGGPSSGAPPPS³

where superscript numbers refer to unique chemical modifications:

  1. "A¹" refers to 2-aminoisobutyric acid (AiB) instead of alanine.
  2. "L²" refers to alpha-methyl added to leucine (MeL, 2-methylleucine).
  3. "S³" refers to addition of an amino group to the C-terminal serine.
  4. "K⁴" refers to a modification group attached to the lysine's tail amine, specifically (AEEA)-gamma-Glu-C20 diacid.

References

  1. ^ Coskun T, Urva S, Roell WC, et al. (September 2022). "LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept". Cell Metabolism. 34 (9): 1234–1247.e9. doi:10.1016/j.cmet.2022.07.013. PMID 35985340. S2CID 251675508.
  2. ^ "Lilly's phase 2 retatrutide results published in The New England Journal of Medicine show the investigational molecule achieved up to 17.5% mean weight reduction at 24 weeks in adults with obesity and overweight". investor.lilly.com (Press release). Eli Lilly. 26 June 2023. Retrieved 3 July 2023.
  3. ^ Constantino, Annika Kim (26 June 2023). "Eli Lilly experimental obesity drug could beat rivals in total weight loss for patients". CNBC.com. Retrieved 3 July 2023.
  4. ^ Jastreboff AM, Kaplan LM, Frías JP, et al. (June 2023). "Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial". The New England Journal of Medicine. 389 (6): 514–526. doi:10.1056/NEJMoa2301972. PMID 37366315. S2CID 259260926. Free access subject to registration.
  5. ^ "Compound Report Card". ebi.ac.uk. European Bioinformatics Institute, European Molecular Biology Laboratory. n.d. Retrieved August 5, 2024.
Stub icon

This pharmacology-related article is a stub. You can help Wikipedia by expanding it.