PTPRH is a topic that has captured the attention and interest of many people over the years. With its lasting impact and its relevance in today's society, PTPRH has generated debate and discussion in different areas. From its beginnings to its evolution, PTPRH has been the subject of study and analysis by experts in the field. In this article, we will explore the different aspects related to PTPRH, from its history to its influence today, with the aim of shedding light on a topic that continues to be exciting and fascinating for many.
Receptor-type tyrosine-protein phosphatase H is an enzyme that in humans is encoded by the PTPRHgene.[5][6]
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues.[6]
Marneros AG, Mehenni H, Reichenberger E, et al. (2001). "Gene for the human transmembrane-type protein tyrosine phosphatase H (PTPRH): genomic structure, fine-mapping and its exclusion as a candidate for Peutz-Jeghers syndrome". Cytogenet. Cell Genet. 92 (3–4): 213–6. doi:10.1159/000056905. PMID11435690. S2CID20187527.
