DUSP18

In this article we will explore DUSP18 from different perspectives, addressing its importance, its effects and its influence on today's society. DUSP18 is a topic that has captured the interest of researchers, professionals and the general public, due to its impact on our lives. From its origin to its evolution today, DUSP18 has been the subject of debate and reflection in various areas, being considered a key element in understanding the contemporary world. Through this article, we will delve into the fascinating world of DUSP18, analyzing its various facets and its role in the current context.

Protein-coding gene in the species Homo sapiens

DUSP18
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ESB
Identifiers
Aliases	DUSP18, DSP18, DUSP20, LMWDSP20, bK963H5.1, dual specificity phosphatase 18
External IDs	OMIM: 611446; MGI: 1922469; HomoloGene: 34984; GeneCards: DUSP18; OMA:DUSP18 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q12.2 Start 30,652,051 bp[1] End 30,667,887 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 A1 Start 3,845,240 bp[2] End 3,851,296 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte bronchial epithelial cell mucosa of ileum left testis right testis testicle mucosa of paranasal sinus sperm right uterine tube blood Top expressed in zygote interventricular septum secondary oocyte myocardium of ventricle Rostral migratory stream dentate gyrus of hippocampal formation granule cell lip islet of Langerhans soleus muscle muscle of thigh More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity MAP kinase tyrosine/serine/threonine phosphatase activity phosphoprotein phosphatase activity hydrolase activity phosphatase activity protein tyrosine/serine/threonine phosphatase activity Cellular component cytoplasm nucleus nucleoplasm mitochondrion membrane mitochondrial inner membrane Biological process protein dephosphorylation peptidyl-tyrosine dephosphorylation peptidyl-threonine dephosphorylation dephosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150290 75219 Ensembl ENSG00000167065 ENSMUSG00000047205 UniProt Q8NEJ0 Q8VE01 RefSeq (mRNA) NM_001304794 NM_001304795 NM_001304796 NM_152511 NM_173745 RefSeq (protein) NP_001291723 NP_001291724 NP_001291725 NP_689724 NP_776106 Location (UCSC) Chr 22: 30.65 – 30.67 Mb Chr 11: 3.85 – 3.85 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase 18 is an enzyme that is encoded by the DUSP18 gene in humans.^[5][6]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000167065 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000047205 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Hood KL, Tobin JF, Yoon C (Oct 2002). "Identification and characterization of two novel low-molecular-weight dual specificity phosphatases". Biochem Biophys Res Commun. 298 (4): 545–51. doi:10.1016/S0006-291X(02)02488-9. PMID 12408986.
6. ^ "Entrez Gene: DUSP18 dual specificity phosphatase 18".

Further reading

• Wu Q, Huang S, Sun Y, et al. (2006). "Dual specificity phosphotase 18, interacting with SAPK, dephosphorylates SAPK and inhibits SAPK/JNK signal pathway in vivo". Front. Biosci. 11: 2714–24. doi:10.2741/2001. PMID 16720344.
• Jeong DG, Cho YH, Yoon TS, et al. (2006). "Structure of human DSP18, a member of the dual-specificity protein tyrosine phosphatase family". Acta Crystallogr. D. 62 (Pt 6): 582–8. Bibcode:2006AcCrD..62..582J. doi:10.1107/S0907444906010109. PMID 16699184.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wu Q, Gu S, Dai J, et al. (2003). "Molecular cloning and characterization of a novel dual-specificity phosphatase18 gene from human fetal brain". Biochim. Biophys. Acta. 1625 (3): 296–304. doi:10.1016/s0167-4781(02)00629-2. PMID 12591617.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Dual specificity protein phosphatase 18 (DUSP18)

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

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