Cl-4AS-1

In today's world, Cl-4AS-1 has become a topic of great relevance and interest to a wide range of people. Whether due to its impact on society, its historical relevance, its influence in the professional field or its connection with current issues, Cl-4AS-1 has captured the attention and curiosity of many. Throughout this article, we will explore different aspects of Cl-4AS-1, from its origin and history to its relevance in the modern world. Without a doubt, Cl-4AS-1 is a topic that leaves no one indifferent, and its importance is evident in various contexts.

Cl-4AS-1
Clinical data
Other namesN-(2-Chlorophenyl)-3-oxo-4-aza-4-methylandrost-1-en-17α-carboxamide
Identifiers
  • (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indenoquinoline-7-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC26H33ClN2O2
Molar mass441.01 g·mol−1
3D model (JSmol)
  • C12CC3(1CC2C(=O)NC4=CC=CC=C4Cl)CC53(C=CC(=O)N5C)C
  • InChI=1S/C26H33ClN2O2/c1-25-14-12-18-16(8-11-22-26(18,2)15-13-23(30)29(22)3)17(25)9-10-19(25)24(31)28-21-7-5-4-6-20(21)27/h4-7,13,15-19,22H,8-12,14H2,1-3H3,(H,28,31)/t16-,17-,18-,19+,22+,25-,26+/m0/s1
  • Key:CTVXDPDUOKQBKZ-GFNRTWGOSA-N

Cl-4AS-1 is a dual anabolic–androgenic steroid (AAS) and 5α-reductase inhibitor.[1][2] It is a potent and selective full agonist of the androgen receptor (IC50 = 12 nM) and inhibitor of 5α-reductase types I and II (IC50 = 6 and 10 nM, respectively).[1][2] Structurally, Cl-4AS-1 is a 4-azasteroid.[1]

See also

References

  1. ^ a b c Tolman RL, Sahoo SP, Bakshi RK, Gratale D, Patel G, Patel S, Toney J, Chang B, Harris GS (1997). "4-Methyl-3-oxo-4-aza-5alpha-androst-1-ene-17beta-N-aryl-carboxamides: an approach to combined androgen blockade ". J. Steroid Biochem. Mol. Biol. 60 (5–6): 303–9. doi:10.1016/s0960-0760(96)00199-9. PMID 9219921. S2CID 54405031.
  2. ^ a b Schmidt A, Harada S, Kimmel DB, Bai C, Chen F, Rutledge SJ, Vogel RL, Scafonas A, Gentile MA, Nantermet PV, McElwee-Witmer S, Pennypacker B, Masarachia P, Sahoo SP, Kim Y, Meissner RS, Hartman GD, Duggan ME, Rodan GA, Towler DA, Ray WJ (2009). "Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands". J. Biol. Chem. 284 (52): 36367–76. doi:10.1074/jbc.M109.049734. PMC 2794752. PMID 19846549.



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