LY305

In today's world, LY305 has become a topic of great relevance and interest to a wide variety of people. Both on a personal and professional level, LY305 has sparked a great debate and a multitude of conflicting opinions. From its origins to its current situation, LY305 has significantly influenced our lives, impacting various aspects of society. In this article, we will explore in depth the different dimensions and perspectives of LY305, analyzing its importance and implications today.

LY305
Legal status
Legal status
  • Investigational
Identifiers
  • 2-Chloro-4-amino]-3-methylbenzonitrile
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
FormulaC14H17ClN2O2
Molar mass280.75 g·mol−1
3D model (JSmol)
  • CC1=C(C=CC(=C1Cl)C#N)N2CCC2(C)O
  • InChI=1S/C14H17ClN2O/c1-9-11(6-5-10(8-16)13(9)15)17-12-4-3-7-14(12,2)18/h5-6,12,17-18H,3-4,7H2,1-2H3/t12-,14-/m1/s1
  • Key:CXFSVKGROITHRY-TZMCWYRMSA-N

LY305 is a transdermally bioavailable selective androgen receptor modulator (SARM) developed by Eli Lilly for the treatment of osteoporosis in men. Its chemical structure includes N-arylhydroxyalkyl. A phase one trial found promising results.[1][2][3]

See also

References

  1. ^ Krishnan, V.; Patel, N. J.; Mackrell, J. G.; Sweetana, S. A.; Bullock, H.; Ma, Y. L.; Waterhouse, T. H.; Yaden, B. C.; Henck, J.; Zeng, Q. Q.; Gavardinas, K.; Jadhav, P.; Saeed, A.; Garcia-Losada, P.; Robins, D. A.; Benson, C. T. (2018). "Development of a selective androgen receptor modulator for transdermal use in hypogonadal patients". Andrology. 6 (3): 455–464. doi:10.1111/andr.12479.
  2. ^ Christiansen, Andrew R.; Lipshultz, Larry I.; Hotaling, James M.; Pastuszak, Alexander W. (March 2020). "Selective androgen receptor modulators: the future of androgen therapy?". Translational Andrology and Urology. 9 (Suppl 2): S135 – S148. doi:10.21037/tau.2019.11.02. ISSN 2223-4683. PMC 7108998. PMID 32257854.
  3. ^ Mohler ML, Sikdar A, Ponnusamy S, Hwang DJ, He Y, Miller DD, Narayanan R. An Overview of Next-Generation Androgen Receptor-Targeted Therapeutics in Development for the Treatment of Prostate Cancer. Int J Mol Sci. 2021 Feb 20;22(4):2124. doi:10.3390/ijms22042124 PMID 33672769