Apricoxib

In this article, we will explore the fascinating history of Apricoxib, a topic that has captured the attention of millions of people around the world. From its origins to its impact on today's society, Apricoxib has left an indelible mark on different aspects of daily life. Over the next few pages, we will immerse ourselves in a journey through time to fully understand the importance of Apricoxib and its influence in various areas. From his contributions in _var2 to the innovations he has pioneered in _var3, Apricoxib has played a crucial role in shaping the world as we know it today. Join us on this exploration as we discover more about Apricoxib's shocking story.

Apricoxib
Legal status
Legal status
  • Investigational
Identifiers
  • 4-benzenesulfonamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC19H20N2O3S
Molar mass356.44 g·mol−1
3D model (JSmol)
  • CCOC1=CC=C(C=C1)C2=CC(=CN2C3=CC=C(C=C3)S(=O)(=O)N)C
  • InChI=1S/C19H20N2O3S/c1-3-24-17-8-4-15(5-9-17)19-12-14(2)13-21(19)16-6-10-18(11-7-16)25(20,22)23/h4-13H,3H2,1-2H3,(H2,20,22,23)
  • Key:JTMITOKKUMVWRT-UHFFFAOYSA-N

Apricoxib is an experimental anticancer drug and nonsteroidal anti-inflammatory drug (NSAID).[1] It is a COX-2 inhibitor which is intended to improve standard therapy response in molecularly-defined models of pancreatic cancer.[2] It was also studied in clinical trials for non-small-cell lung cancer.[3] Development was abandoned in 2015 due to poor clinical trial results.[4]

See also

References

  1. ^ "Apricoxib (Code C74021)". NCI Thesaurus. National Cancer Institute.
  2. ^ Kirane A, Toombs JE, Ostapoff K, Carbon JG, Zaknoen S, Braunfeld J, et al. (September 2012). "Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer". Clinical Cancer Research. 18 (18): 5031–42. doi:10.1158/1078-0432.CCR-12-0453. PMC 3777527. PMID 22829202.
  3. ^ Edelman MJ, Tan MT, Fidler MJ, Sanborn RE, Otterson G, Sequist LV, et al. (January 2015). "Randomized, double-blind, placebo-controlled, multicenter phase II study of the efficacy and safety of apricoxib in combination with either docetaxel or pemetrexed in patients with biomarker-selected non-small-cell lung cancer". Journal of Clinical Oncology. 33 (2): 189–94. doi:10.1200/JCO.2014.55.5789. PMC 4890680. PMID 25452446.
  4. ^ "Apricoxib". Adis Insight. Springer Nature Switzerland AG.
Stub icon

This drug article relating to the musculoskeletal system is a stub. You can help Wikipedia by expanding it.