Zinc transporter ZIP4

In today's article, we will explore the fascinating world of Zinc transporter ZIP4. From its origins to its relevance in today's society, we will thoroughly examine all aspects related to this topic. We will analyze its impacts in different areas, such as economy, culture, science and technology, to understand its importance and influence on our daily lives. Throughout this article, we will learn about the various perspectives and opinions of experts on the subject, as well as testimonies from people who have participated in experiences related to Zinc transporter ZIP4. Get ready to embark on a journey of discovery and learning that will leave you with a broader and enriching vision about Zinc transporter ZIP4.

Protein found in humans

SLC39A4
Identifiers
Aliases	SLC39A4, AEZ, AWMS2, ZIP4, solute carrier family 39 member 4
External IDs	OMIM: 607059; MGI: 1919277; HomoloGene: 15638; GeneCards: SLC39A4; OMA:SLC39A4 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,409,742 bp[1] End 144,416,844 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,496,583 bp[2] End 76,501,584 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum mucosa of transverse colon human kidney renal cortex body of stomach left lobe of thyroid gland fundus right ovary right lobe of thyroid gland skin of abdomen Top expressed in jejunum duodenum yolk sac ileum choroid plexus of fourth ventricle epithelium of small intestine intestinal villus left lobe of liver right lung lobe left colon More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion transmembrane transporter activity zinc ion transmembrane transporter activity Cellular component integral component of membrane endosome recycling endosome membrane plasma membrane membrane integral component of plasma membrane cytoplasmic vesicle apical plasma membrane Biological process metal ion transport zinc ion transport ion transport zinc ion import across plasma membrane transmembrane transport signal transduction cellular zinc ion homeostasis cellular response to zinc ion starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55630 72027 Ensembl ENSG00000147804 ENSG00000285243 ENSMUSG00000063354 UniProt Q6P5W5 Q78IQ7 RefSeq (mRNA) NM_001280557 NM_017767 NM_130849 NM_001374839 NM_028064 RefSeq (protein) NP_001267486 NP_060237 NP_570901 NP_001361768 NP_082340 Location (UCSC) Chr 8: 144.41 – 144.42 Mb Chr 15: 76.5 – 76.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter ZIP4 is a transmembrane protein which in humans is encoded by the SLC39A4 gene. It is associated with acrodermatitis enteropathica.^[5]

See also

• Solute carrier family

References

1. ^ ^{a b c} ENSG00000285243 GRCh38: Ensembl release 89: ENSG00000147804, ENSG00000285243 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000063354 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Kambe T, Andrews GK (January 2009). "Novel proteolytic processing of the ectodomain of the zinc transporter ZIP4 (SLC39A4) during zinc deficiency is inhibited by acrodermatitis enteropathica mutations". Molecular and Cellular Biology. 29 (1): 129–139. doi:10.1128/MCB.00963-08. PMC 2612479. PMID 18936158.

External links

• OMIM entry on ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE; AEZ

• Beigi PK, Maverakis E (2015). Acrodermatitis Enteropathica: A Clinician's Guide. Springer. ISBN 978-3-319-17819-6. Retrieved 18 February 2017.

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