Vaniprevir

Today, Vaniprevir is a topic that has captured the attention of people of all ages and interests. From its impact on society to its influence on popular culture, Vaniprevir has proven to be a relevant and significant topic today. In this article, we will explore the different aspects of Vaniprevir, from its history and evolution to its impact on daily life. Additionally, we will examine the different perspectives on Vaniprevir and how it has changed over time. Without a doubt, Vaniprevir is a topic that will continue to generate debate and reflection in the future.

Vaniprevir
Identifiers
  • (1R,21S,24S)-21-tert-butyl-N--16,16-dimethyl-3,19,22-trioxo-2,18-dioxa-4,20,23-triazatetracycloheptacosa-6(11),7,9-triene-24-carboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.207.830 Edit this at Wikidata
Chemical and physical data
FormulaC38H55N5O9S
Molar mass757.94 g·mol−1
3D model (JSmol)
  • CC1C1(C(=O)NS(=O)(=O)C2CC2)NC(=O)3C4CN3C(=O)(NC(=O)OCC(CCCCC5=C6CN(CC6=CC=C5)C(=O)O4)(C)C)C(C)(C)C
  • InChI=InChI=1S/C38H55N5O9S/c1-7-25-18-38(25,33(46)41-53(49,50)27-14-15-27)40-31(44)29-17-26-20-43(29)32(45)30(36(2,3)4)39-34(47)51-22-37(5,6)16-9-8-11-23-12-10-13-24-19-42(21-28(23)24)35(48)52-26/h10,12-13,25-27,29-30H,7-9,11,14-22H2,1-6H3,(H,39,47)(H,40,44)(H,41,46)/t25-,26-,29+,30-,38-/m1/s1
  • Key:KUQWGLQLLVFLSM-ONAXAZCASA-N

Vaniprevir (MK-7009) is a macrocyclic hepatitis C virus (HCV) NS3/4A protease inhibitor, developed by Merck & Co., which is currently in clinical testing.[1] In Japan, it was approved for treating hepatitis C in 2014 under the brand name Vanihep.[2][3]

References

  1. ^ McCauley JA, McIntyre CJ, Rudd MT, Nguyen KT, Romano JJ, Butcher JW, et al. (March 2010). "Discovery of vaniprevir (MK-7009), a macrocyclic hepatitis C virus NS3/4a protease inhibitor". J. Med. Chem. 53 (6): 2443–63. doi:10.1021/jm9015526. PMID 20163176.
  2. ^ "First recommendation for HCV drug vaniprevir, in Japan". datamonitorhealthcare.com. September 25, 2014.
  3. ^ "New Drugs Approved" (PDF). Pharmaceuticals and Medical Devices Agency. Archived from the original (PDF) on 2015-05-13. Retrieved 2015-08-22.
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