Troponin T

In this article we are going to delve into the exciting world of Troponin T. From its origins to its relevance today, this topic/person/date has captured the attention of countless individuals throughout history. Through this writing, we will explore its different facets, analyze its impact on society and reflect on its influence in various areas. Without a doubt, Troponin T is a topic of great interest that deserves to be explored and understood in depth.

"TnT" redirects here. For other uses, see TNT (disambiguation).
Troponin T
Troponin
Test ofTroponin
Cardiac sarcomere structure featuring troponin T

Troponin T (shortened TnT[1] or TropT) is a part of the troponin complex, which are proteins integral to the contraction of skeletal and heart muscles. They are expressed in skeletal and cardiac myocytes. Troponin T binds to tropomyosin and helps position it on actin,[2] and together with the rest of the troponin complex, modulates contraction of striated muscle.[3] The cardiac subtype of troponin T is especially useful in the laboratory diagnosis of heart attack because it is released into the blood-stream when damage to heart muscle occurs.[4] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg, who also developed the troponin T assay.

Subtypes

Reference values

The 99th percentile cutoff for cardiac troponin T (cTnT) is 0.01 ng/mL.[5] The reference range for the high sensitivity troponin T is a normal < 14 ng/L, borderline of 14-52 ng/L, and elevated of >52 ng/L.[6]

Background

The troponin complex is responsible for coupling the sarcomere contraction cycle to variations in intracellular calcium concentration. Increased troponin T levels after an episode of chest pain indicates myocardial infarction.[7] It was discovered by the German physician Hugo A. Katus at the University of Heidelberg. He also developed the troponin T assay.[8] In patients with non-severe asymptomatic aortic valve stenosis and no overt coronary artery disease, the increased troponin T (above 14 pg/mL) was found associated with an increased 5-year event rate of ischemic cardiac events (myocardial infarction, percutaneous coronary intervention, or coronary artery bypass surgery).[9] In patients with stable coronary artery disease, the troponin T concentration has long been found to be significantly associated with the incidence of cardiovascular death and heart failure, but it was 2014 before it began to be accepted as a predictor of who would later suffer acute myocardial infarction (heart attack).[10][11]

See also

References

  1. ^ Jin, Jian-Ping (2016-01-01), Jeon, Kwang W. (ed.), "Chapter One - Evolution, Regulation, and Function of N-terminal Variable Region of Troponin T: Modulation of Muscle Contractility and Beyond", International Review of Cell and Molecular Biology, 321, Academic Press: 1–28, doi:10.1016/bs.ircmb.2015.09.002, PMID 26811285
  2. ^ marieb, elaine (2004)
  3. ^ black, joyce (2005)
  4. ^ Braunwald's Heart Disease. Elsevier Saunders. 2015. p. 433. ISBN 978-1-4557-5134-1.
  5. ^ Ashvarya Mangla. "Troponins". medscape. Retrieved 2017-07-24. Updated: Jan 14, 2015
  6. ^ "Troponin T, High Sensitivity". www.calgarylabservices.com. Retrieved 29 August 2019.
  7. ^ Michael A. Chen. "Troponin test". MedlinePlus, U.S. National Library of Medicine. Retrieved 2017-07-24. Review Date 10/6/2015
  8. ^ "Development of the Cardiac Troponin T Immunoassay". American Association for Clinical Chemistry, Inc. 2008. Retrieved 2010-05-01.
  9. ^ Hadziselimovic, Edina; Greve, Anders M.; Sajadieh, Ahmad; Olsen, Michael H.; Kesäniemi, Y. Antero; Nienaber, Christoph A.; Ray, Simon G.; Rossebø, Anne B.; Wachtell, Kristian; Nielsen, Olav W. (April 2023). "Association of high-sensitivity troponin T with outcomes in asymptomatic non-severe aortic stenosis: a post-hoc substudy of the SEAS trial". eClinicalMedicine. 58: 101875. doi:10.1016/j.eclinm.2023.101875. ISSN 2589-5370. PMC 10006443. PMID 36915288.
  10. ^ Omland, Torbjørn; De Lemos, James A.; Sabatine, Marc S.; Christophi, Costas A.; Rice, Madeline Murguia; Jablonski, Kathleen A.; Tjora, Solve; Domanski, Michael J.; Gersh, Bernard J.; Rouleau, Jean L.; Pfeffer, Marc A.; Braunwald, Eugene (2009). "A Sensitive Cardiac Troponin T Assay in Stable Coronary Artery Disease". New England Journal of Medicine. 361 (26): 2538–2547. doi:10.1056/NEJMoa0805299. PMC 2997684. PMID 19940289.
  11. ^ "Health Conditions: Diseases, conditions & medical information - MSN Health & Fitness". healthyliving.msn.com. Retrieved 12 April 2018.[permanent dead link‍]