TP53INP1

In this article, we will explore the topic of TP53INP1 from different perspectives with the aim of analyzing and understanding its importance in today's society. TP53INP1 is a topic of great relevance today, since it impacts numerous aspects of daily life and plays a fundamental role in personal, professional and social development. Through detailed analysis, we will address the different facets of TP53INP1, examining its implications, challenges and opportunities. Likewise, we will delve into research and studies that offer a deeper insight into TP53INP1 and its influence in different contexts. We hope that this article provides an enriching and stimulating perspective on TP53INP1, encouraging debate and reflection on this very relevant topic.

Protein-coding gene in the species Homo sapiens

TP53INP1
Identifiers
Aliases	TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1, tumor protein p53 inducible nuclear protein 1
External IDs	OMIM: 606185; MGI: 1926609; HomoloGene: 11065; GeneCards: TP53INP1; OMA:TP53INP1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.1 Start 94,925,972 bp[1] End 94,949,378 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A1 Start 11,156,431 bp[2] End 11,174,379 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm epithelium of nasopharynx thymus bronchial epithelial cell mucosa of ileum body of pancreas visceral pleura parietal pleura germinal epithelium palpebral conjunctiva Top expressed in stroma of bone marrow lymph node thymus mesenteric lymph nodes Paneth cell vestibular membrane of cochlear duct ascending aorta utricle blood pituitary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function antioxidant activity protein binding Cellular component cytosol PML body autophagosome cytoplasmic vesicle nucleus nucleoplasm cytoplasm Biological process regulation of transcription, DNA-templated cellular response to ethanol positive regulation of autophagy cellular response to methyl methanesulfonate cellular response to UV cellular oxidant detoxification positive regulation of apoptotic signaling pathway response to heat autophagosome assembly transcription, DNA-templated cellular response to hydroperoxide positive regulation of transcription, DNA-templated autophagy negative regulation of cell migration regulation of autophagy positive regulation of apoptotic process autophagic cell death negative regulation of cell population proliferation apoptotic process regulation of apoptotic process regulation of signal transduction by p53 class mediator positive regulation of gene expression negative regulation of gene expression negative regulation of fibroblast proliferation negative regulation of myofibroblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94241 60599 Ensembl ENSG00000164938 ENSMUSG00000028211 UniProt Q96A56 Q9QXE4 RefSeq (mRNA) NM_001135733 NM_033285 NM_001199105 NM_021897 RefSeq (protein) NP_001129205 NP_150601 NP_001186034 NP_068697 Location (UCSC) Chr 8: 94.93 – 94.95 Mb Chr 4: 11.16 – 11.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.^[5][6][7] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein".

Interactions

TP53INP1 has been shown to interact with HIPK2^[8] and p53.^[5][8]

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000164938 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000028211 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ ^{a b} Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y (Aug 2001). "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85–94. doi:10.1016/S1097-2765(01)00284-2. PMID 11511362.
6. ^ Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ (Nov 2002). "Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization". Cytogenet Genome Res. 97 (1–2): 140E. doi:10.1159/000064049. PMID 12438758.
7. ^ "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1".
8. ^ ^{a b} Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. 278 (39). United States: 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404.

Further reading

• Tomasini R, Samir AA, Pebusque MJ, et al. (2003). "P53-dependent expression of the stress-induced protein (SIP)". Eur. J. Cell Biol. 81 (5): 294–301. doi:10.1078/0171-9335-00248. PMID 12067065.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Tomasini R, Samir AA, Carrier A, et al. (2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. 278 (39): 37722–9. doi:10.1074/jbc.M301979200. PMID 12851404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hershko T, Chaussepied M, Oren M, Ginsberg D (2005). "Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F". Cell Death Differ. 12 (4): 377–83. doi:10.1038/sj.cdd.4401575. PMID 15706352.
• Tomasini R, Seux M, Nowak J, et al. (2006). "TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity". Oncogene. 24 (55): 8093–104. doi:10.1038/sj.onc.1208951. PMID 16044147.
• Jiang PH, Motoo Y, Garcia S, et al. (2006). "Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer". World J. Gastroenterol. 12 (5): 691–6. doi:10.3748/wjg.v12.i5.691. PMC 4066117. PMID 16521180.
• Ito Y, Motoo Y, Yoshida H, et al. (2007). "High level of tumour protein p53-induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid". Pathology. 38 (6): 545–7. doi:10.1080/00313020601024094. PMID 17393983. S2CID 28578199.
• Bernardo MV, Yelo E, Gimeno L, et al. (2007). "Identification of apoptosis-related PLZF target genes". Biochem. Biophys. Res. Commun. 359 (2): 317–22. doi:10.1016/j.bbrc.2007.05.085. PMID 17537403.

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