SERPINB13

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Gene of the species Homo sapiens

SERPINB13
Identifiers
Aliases	SERPINB13, HSHUR7SEQ, HUR7, PI13, headpin, serpin family B member 13
External IDs	OMIM: 604445; MGI: 3042250; HomoloGene: 22718; GeneCards: SERPINB13; OMA:SERPINB13 - orthologs
Gene location (Mouse) Chr. Chromosome 1 (mouse)[1] Band 1|1 E2.1 Start 106,908,714 bp[1] End 106,928,925 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in esophagus lip zone of skin stomach BioGPS More reference expression data
Gene ontology Molecular function peptidase inhibitor activity protease binding cysteine-type endopeptidase inhibitor activity serine-type endopeptidase inhibitor activity Cellular component cytoplasm extracellular exosome nucleolus nucleoplasm extracellular space cytosol nuclear speck lysosomal lumen Biological process negative regulation of peptidase activity response to UV regulation of proteolysis negative regulation of endopeptidase activity negative regulation of keratinocyte apoptotic process regulation of keratinocyte differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5275 241196 Ensembl ENSG00000197641 ENSMUSG00000048775 UniProt Q9UIV8 Q8CDC0 RefSeq (mRNA) NM_001307923 NM_012397 NM_172852 RefSeq (protein) NP_001294852 NP_036529 NP_001335196 NP_001335197 NP_001335198 NP_001335199 NP_766440 Location (UCSC) n/a Chr 1: 106.91 – 106.93 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Serpin B13 is a protein that in humans is encoded by the SERPINB13 gene.^[4][5][6]

See also

• Serpin

References

1. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000048775 – Ensembl, May 2017
2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ Abts HF, Breuhahn K, Michel G, Kohrer K, Esser P, Ruzicka T (Oct 1997). "Analysis of UVB-modulated gene expression in human keratinocytes by mRNA differential display polymerase chain reaction". Photochem Photobiol. 66 (3): 363–7. doi:10.1111/j.1751-1097.1997.tb03159.x. PMID 9297979. S2CID 39471133.
5. ^ Abts HF, Welss T, Mirmohammadsadegh A, Kohrer K, Michel G, Ruzicka T (Nov 1999). "Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family". J Mol Biol. 293 (1): 29–39. doi:10.1006/jmbi.1999.3159. PMID 10512713.
6. ^ "Entrez Gene: SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13".

Further reading

• Spring P, Nakashima T, Frederick M, et al. (1999). "Identification and cDNA cloning of headpin, a novel differentially expressed serpin that maps to chromosome 18q". Biochem. Biophys. Res. Commun. 264 (1): 299–304. doi:10.1006/bbrc.1999.1453. PMID 10527881.
• Nakashima T, Pak SC, Silverman GA, et al. (2000). "Genomic cloning, mapping, structure and promoter analysis of HEADPIN, a serpin which is down-regulated in head and neck cancer cells". Biochim. Biophys. Acta. 1492 (2–3): 441–6. doi:10.1016/s0167-4781(00)00100-7. PMID 11004515.
• Abts HF, Welss T, Scheuring S, et al. (2001). "Sequence, organization, chromosomal localization, and alternative splicing of the human serine protease inhibitor gene hurpin (PI13) which is upregulated in psoriasis". DNA Cell Biol. 20 (3): 123–31. doi:10.1089/104454901300068924. PMID 11313015.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Jayakumar A, Kang Y, Frederick MJ, et al. (2003). "Inhibition of the cysteine proteinases cathepsins K and L by the serpin headpin (SERPINB13): a kinetic analysis". Arch. Biochem. Biophys. 409 (2): 367–74. doi:10.1016/S0003-9861(02)00635-5. PMID 12504904.
• Welss T, Sun J, Irving JA, et al. (2003). "Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis". Biochemistry. 42 (24): 7381–9. doi:10.1021/bi027307q. PMID 12809493.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Moussali H, Bylaite M, Welss T, et al. (2005). "Expression of hurpin, a serine proteinase inhibitor, in normal and pathological skin: overexpression and redistribution in psoriasis and cutaneous carcinomas". Exp. Dermatol. 14 (6): 420–8. doi:10.1111/j.0906-6705.2005.00300.x. PMID 15885077. S2CID 39830943.
• Shellenberger TD, Mazumdar A, Henderson Y, et al. (2006). "Headpin: a serpin with endogenous and exogenous suppression of angiogenesis". Cancer Res. 65 (24): 11501–9. doi:10.1158/0008-5472.CAN-05-2262. PMID 16357159.
• Bylaite M, Moussali H, Marciukaitiene I, et al. (2006). "Expression of cathepsin L and its inhibitor hurpin in inflammatory and neoplastic skin diseases". Exp. Dermatol. 15 (2): 110–8. doi:10.1111/j.1600-0625.2005.00389.x. PMID 16433682. S2CID 26784268.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.017
• SERPINB13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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